Rtt109 prevents hyper-amplification of ribosomal RNA genes through histone modification in budding yeast

The genes encoding ribosomal RNA are the most abundant in the eukaryotic genome. They reside in tandem repetitive clusters, in some cases totaling hundreds of copies. Due to their repetitive structure, ribosomal RNA genes (rDNA) are easily lost by recombination events within the repeated cluster. We...

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Veröffentlicht in:	PLoS genetics 2013-04, Vol.9 (4), p.e1003410-e1003410
Hauptverfasser:	Ide, Satoru, Saka, Kimiko, Kobayashi, Takehiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Biology Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism Chromatids - genetics Chromatids - metabolism Chromosomal Proteins, Non-Histone - genetics Chromosomal Proteins, Non-Histone - metabolism Cohesins Control Deoxyribonucleic acid DNA DNA Replication - genetics DNA-Binding Proteins - genetics Gene amplification Genetic regulation Genetics Genome, Fungal Histone Acetyltransferases - genetics Histone Acetyltransferases - metabolism Histones - genetics Microbiology Properties Proteins Recombination, Genetic Ribosomal RNA RNA, Ribosomal - genetics Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae Proteins - genetics Saccharomyces cerevisiae Proteins - metabolism Testing Yeast
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