Balancing selection on a regulatory region exhibiting ancient variation that predates human-neandertal divergence

Ancient population structure shaping contemporary genetic variation has been recently appreciated and has important implications regarding our understanding of the structure of modern human genomes. We identified a ∼36-kb DNA segment in the human genome that displays an ancient substructure. The var...

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Veröffentlicht in:	PLoS genetics 2013-04, Vol.9 (4), p.e1003404
Hauptverfasser:	Gokcumen, Omer, Zhu, Qihui, Mulder, Lubbertus C F, Iskow, Rebecca C, Austermann, Christian, Scharer, Christopher D, Raj, Towfique, Boss, Jeremy M, Sunyaev, Shamil, Price, Alkes, Stranger, Barbara, Simon, Viviana, Lee, Charles
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Animals Base Sequence Biology Ethnic Groups - genetics European Continental Ancestry Group Experiments Genetic diversity Genetic Variation Genetics, Population Genome, Human Genomes Genomics Haplotypes Harbors Human genome Humans Identification and classification Neanderthals - genetics Neanderthals - physiology Pan troglodytes - genetics Phylogeny Polymorphism, Single Nucleotide Properties Quantitative trait loci Selection, Genetic Sequence Deletion - genetics Testing
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