Klf4 is a transcriptional regulator of genes critical for EMT, including Jnk1 (Mapk8)

We have identified the zinc-finger transcription factor Kruppel-like factor 4 (Klf4) among the transcription factors that are significantly downregulated in their expression during epithelial-mesenchymal transition (EMT) in mammary epithelial cells and in breast cancer cells. Loss and gain of functi...

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Veröffentlicht in:	PloS one 2013-02, Vol.8 (2), p.e57329-e57329
Hauptverfasser:	Tiwari, Neha, Meyer-Schaller, Nathalie, Arnold, Phil, Antoniadis, Helena, Pachkov, Mikhail, van Nimwegen, Erik, Christofori, Gerhard
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Bioinformatics Biology Breast cancer Cancer Cancer metastasis Cell adhesion & migration Cell cycle Cell Differentiation Cell migration Chromatin Cyclin-dependent kinases DNA binding proteins DNA methylation E-cadherin Endothelin 1 Endothelins Epithelial cells Epithelial-Mesenchymal Transition - physiology Gene expression Gene regulation Gene sequencing Genes Genetic aspects Genomes Immunoprecipitation Intermediate filament proteins JNK protein Kinases KLF4 protein Krueppel-like factor Kruppel-Like Transcription Factors - physiology Mammary gland Medicine Mesenchyme Metastases Metastasis Mice Mitogen-Activated Protein Kinase 8 - physiology Morphology N-Cadherin Neoplasms, Experimental - pathology Rodents Stem cells Trans-Activators - physiology Transcription (Genetics) Transcription factors Transforming growth factors Vascular endothelial growth factor Vimentin Zinc Zinc finger proteins β-Catenin
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