Cytotoxic chromosomal targeting by CRISPR/Cas systems can reshape bacterial genomes and expel or remodel pathogenicity islands

In prokaryotes, clustered regularly interspaced short palindromic repeats (CRISPRs) and their associated (Cas) proteins constitute a defence system against bacteriophages and plasmids. CRISPR/Cas systems acquire short spacer sequences from foreign genetic elements and incorporate these into their CR...

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Veröffentlicht in:	PLoS genetics 2013-04, Vol.9 (4), p.e1003454
Hauptverfasser:	Vercoe, Reuben B, Chang, James T, Dy, Ron L, Taylor, Corinda, Gristwood, Tamzin, Clulow, James S, Richter, Corinna, Przybilski, Rita, Pitman, Andrew R, Fineran, Peter C
Format:	Artikel
Sprache:	eng
Schlagworte:	Arrays Bacteria Bacterial genetics Bacteriophages Biology Chromosomes Clustered Regularly Interspaced Short Palindromic Repeats Colleges & universities CRISPR-Cas Systems Cytotoxicity Deoxyribonucleic acid DNA Genetic aspects Genome, Bacterial Genomes Genomic Islands Health aspects Immune system Islands Microbiology Mutation Physiological aspects Plasmids Prokaryotes
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