Rab6a/a' are important Golgi regulators of pro-inflammatory TNF secretion in macrophages

Lipopolysaccharide (LPS)-activated macrophages secrete pro-inflammatory cytokines, including tumor necrosis factor (TNF) to elicit innate immune responses. Secretion of these cytokines is also a major contributing factor in chronic inflammatory disease. In previous studies we have begun to elucidate...

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Veröffentlicht in:	PloS one 2013-02, Vol.8 (2), p.e57034-e57034
Hauptverfasser:	Micaroni, Massimo, Stanley, Amanda C, Khromykh, Tatiana, Venturato, Juliana, Wong, Colin X F, Lim, Jet P, Marsh, Brad J, Storrie, Brian, Gleeson, Paul A, Stow, Jennifer L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autoantigens - metabolism Biochemistry Biology Brefeldin A - pharmacology Carriers Cell cycle Cell Line Cell Membrane - metabolism Cell surface Cytokines Depletion Egress Elongated structure G proteins Golgi apparatus Golgi Apparatus - metabolism Golgi Matrix Proteins Immune response Innate immunity Isoforms Legionella Lipopolysaccharides Macrophages Macrophages - metabolism Membrane Proteins - metabolism Membranes Mice Mitogens Molecular biology Mutants Mutation Protein Stability Protein Transport - drug effects Proteins rab GTP-Binding Proteins - genetics rab GTP-Binding Proteins - metabolism Regulators RNA Interference Rodents siRNA Transport Tubules Tumor necrosis factor Tumor necrosis factor-TNF Tumor Necrosis Factors - metabolism
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