Increased rate of arterial stiffening with obesity in adolescents: a five-year follow-up study
We prospectively and longitudinally determined the effects of childhood obesity on arterial stiffening and vascular wall changes. Changes in arterial stiffness measured as pulse wave velocity (PWV) and vascular morphology of the radial (RA) and dorsal pedal arteries (DPA) were examined in obese adol...
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| description | We prospectively and longitudinally determined the effects of childhood obesity on arterial stiffening and vascular wall changes. Changes in arterial stiffness measured as pulse wave velocity (PWV) and vascular morphology of the radial (RA) and dorsal pedal arteries (DPA) were examined in obese adolescents compared to lean subjects in a 5-year follow-up study.
A total of 28 obese subjects and 14 lean controls participated in both baseline (14 years old) and follow-up studies. PWV was measured by tonometer (SphygmoCor®) and recorded at RA and carotid artery, respectively. Intima thickness (IT), intima-media thickness (IMT) and RA and DPA diameters were measured using high-resolution ultrasound (Vevo 770™). Over the course of 5 years, PWV increased by 25% in the obese subjects as compared to 3% in the controls (p = 0.01). Diastolic blood pressure (DBP) increased by 23% in the obese subjects as opposed to 6% in controls (p = 0.009). BMI increased similarly in both groups, as did the IT and IMT. The change in PWV was strongly associated to the baseline BMI z -score (r = 0.51, p |
| doi_str_mv | 10.1371/journal.pone.0057454 |
| format | Article |
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A total of 28 obese subjects and 14 lean controls participated in both baseline (14 years old) and follow-up studies. PWV was measured by tonometer (SphygmoCor®) and recorded at RA and carotid artery, respectively. Intima thickness (IT), intima-media thickness (IMT) and RA and DPA diameters were measured using high-resolution ultrasound (Vevo 770™). Over the course of 5 years, PWV increased by 25% in the obese subjects as compared to 3% in the controls (p = 0.01). Diastolic blood pressure (DBP) increased by 23% in the obese subjects as opposed to 6% in controls (p = 0.009). BMI increased similarly in both groups, as did the IT and IMT. The change in PWV was strongly associated to the baseline BMI z -score (r = 0.51, p<0.001), as was the change in DBP (r = 0.50, p = 0.001).
During the transition from early to late adolescence, there was a general increase in arterial stiffness, which was aggravated by childhood obesity. The increase in arterial stiffness and DBP after 5 years was closely correlated to the baseline BMI z -score, indicating that childhood obesity has an adverse impact on vascular adaptation.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0057454</identifier><identifier>PMID: 23451232</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adolescent ; Adolescent obesity ; Adolescents ; all-cause ; Arteries ; Blood Flow Velocity - physiology ; Blood pressure ; Body mass ; Body mass index ; cardiovascular risk-factors ; Carotid Arteries - pathology ; Carotid artery ; Case-Control Studies ; childhood ; Childhood obesity ; Children ; Comparative analysis ; Follow-Up Studies ; Fysiologi och anatomi ; Health risk assessment ; Humans ; Longitudinal Studies ; Medicine ; Obesity ; Obesity - pathology ; Physiology and Anatomy ; Prospective Studies ; pulse-wave velocity ; Stiffening ; Stiffness ; Teenagers ; Tunica Intima - pathology ; Ultrasound ; Vascular Stiffness - physiology ; Veins & arteries ; wall thickness ; Wave velocity ; young finns ; Youth</subject><ispartof>PloS one, 2013-02, Vol.8 (2), p.e57454-e57454</ispartof><rights>COPYRIGHT 2013 Public Library of Science</rights><rights>2013 Dangardt et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2013 Dangardt et al 2013 Dangardt et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c730t-2431cf8e20da21653a56848561cca15de7cfd6ea401fb86c345bc510b741025b3</citedby><cites>FETCH-LOGICAL-c730t-2431cf8e20da21653a56848561cca15de7cfd6ea401fb86c345bc510b741025b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3579778/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3579778/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,550,723,776,780,860,881,2096,2915,23847,27903,27904,53769,53771,79346,79347</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23451232$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://gup.ub.gu.se/publication/176356$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><contributor>Kirchmair, Rudolf</contributor><creatorcontrib>Dangardt, Frida</creatorcontrib><creatorcontrib>Chen, Yun</creatorcontrib><creatorcontrib>Berggren, Krister</creatorcontrib><creatorcontrib>Osika, Walter</creatorcontrib><creatorcontrib>Friberg, Peter</creatorcontrib><title>Increased rate of arterial stiffening with obesity in adolescents: a five-year follow-up study</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>We prospectively and longitudinally determined the effects of childhood obesity on arterial stiffening and vascular wall changes. Changes in arterial stiffness measured as pulse wave velocity (PWV) and vascular morphology of the radial (RA) and dorsal pedal arteries (DPA) were examined in obese adolescents compared to lean subjects in a 5-year follow-up study.
A total of 28 obese subjects and 14 lean controls participated in both baseline (14 years old) and follow-up studies. PWV was measured by tonometer (SphygmoCor®) and recorded at RA and carotid artery, respectively. Intima thickness (IT), intima-media thickness (IMT) and RA and DPA diameters were measured using high-resolution ultrasound (Vevo 770™). Over the course of 5 years, PWV increased by 25% in the obese subjects as compared to 3% in the controls (p = 0.01). Diastolic blood pressure (DBP) increased by 23% in the obese subjects as opposed to 6% in controls (p = 0.009). BMI increased similarly in both groups, as did the IT and IMT. The change in PWV was strongly associated to the baseline BMI z -score (r = 0.51, p<0.001), as was the change in DBP (r = 0.50, p = 0.001).
During the transition from early to late adolescence, there was a general increase in arterial stiffness, which was aggravated by childhood obesity. The increase in arterial stiffness and DBP after 5 years was closely correlated to the baseline BMI z -score, indicating that childhood obesity has an adverse impact on vascular adaptation.</description><subject>Adolescent</subject><subject>Adolescent obesity</subject><subject>Adolescents</subject><subject>all-cause</subject><subject>Arteries</subject><subject>Blood Flow Velocity - physiology</subject><subject>Blood pressure</subject><subject>Body mass</subject><subject>Body mass index</subject><subject>cardiovascular risk-factors</subject><subject>Carotid Arteries - pathology</subject><subject>Carotid artery</subject><subject>Case-Control Studies</subject><subject>childhood</subject><subject>Childhood obesity</subject><subject>Children</subject><subject>Comparative analysis</subject><subject>Follow-Up Studies</subject><subject>Fysiologi och anatomi</subject><subject>Health risk assessment</subject><subject>Humans</subject><subject>Longitudinal Studies</subject><subject>Medicine</subject><subject>Obesity</subject><subject>Obesity - pathology</subject><subject>Physiology and Anatomy</subject><subject>Prospective Studies</subject><subject>pulse-wave velocity</subject><subject>Stiffening</subject><subject>Stiffness</subject><subject>Teenagers</subject><subject>Tunica Intima - pathology</subject><subject>Ultrasound</subject><subject>Vascular Stiffness - physiology</subject><subject>Veins & arteries</subject><subject>wall thickness</subject><subject>Wave velocity</subject><subject>young finns</subject><subject>Youth</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>D8T</sourceid><sourceid>DOA</sourceid><recordid>eNqNk12L1DAUhoso7rr6D0QLguhFx3w16XghLIsfAwsLfl0a0vSkkyHTzCbtjvPvzTjdZSp7IQ20nDzv25y3PVn2HKMZpgK_W_khdMrNNr6DGUKlYCV7kJ3iOSUFJ4g-PHo-yZ7EuEoQrTh_nJ0QykpMKDnNfi06HUBFaPKgesi9yVXoIVjl8thbY6CzXZtvbb_MfQ3R9rvcdrlqvIOooevj-1zlxt5AsQMVcuOd89ti2CT10OyeZo-MchGejfez7Menj98vvhSXV58XF-eXhRYU9QVhFGtTAUGNIpiXVJW8YlXJsdYKlw0IbRoOiiFs6orrdPxalxjVgmFEypqeZS8PvhvnoxyjiRLTMq2KEZqIxYFovFrJTbBrFXbSKyv_FnxoZWrcageSVIpo1GjAHLMK0drUChrFsOZYAIPkVRy84hY2Qz1xa4eNTKV2kBEkFpyWPPEfxtMN9RqafWxBuYlsutPZpWz9jaSlmAtRJYM3o0Hw1wPEXq5tSt851YEf9n1iRumcsnlCX_2D3p_GSLUqNWw749N79d5UnjNRYS5wRRI1u4dKVwNrq9N_Z2yqTwRvJ4LE9PC7b9UQo1x8-_r_7NXPKfv6iF2Ccv0yejf01ndxCrIDqIOPMYC5CxkjuR-b2zTkfmzkODZJ9uL4A92JbueE_gHPphLr</recordid><startdate>20130222</startdate><enddate>20130222</enddate><creator>Dangardt, Frida</creator><creator>Chen, Yun</creator><creator>Berggren, Krister</creator><creator>Osika, Walter</creator><creator>Friberg, Peter</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>AAOVB</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>D8T</scope><scope>F1U</scope><scope>ZZAVC</scope><scope>DOA</scope></search><sort><creationdate>20130222</creationdate><title>Increased rate of arterial stiffening with obesity in adolescents: a five-year follow-up study</title><author>Dangardt, Frida ; Chen, Yun ; Berggren, Krister ; Osika, Walter ; Friberg, Peter</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c730t-2431cf8e20da21653a56848561cca15de7cfd6ea401fb86c345bc510b741025b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adolescent</topic><topic>Adolescent obesity</topic><topic>Adolescents</topic><topic>all-cause</topic><topic>Arteries</topic><topic>Blood Flow Velocity - physiology</topic><topic>Blood pressure</topic><topic>Body mass</topic><topic>Body mass index</topic><topic>cardiovascular risk-factors</topic><topic>Carotid Arteries - pathology</topic><topic>Carotid artery</topic><topic>Case-Control Studies</topic><topic>childhood</topic><topic>Childhood obesity</topic><topic>Children</topic><topic>Comparative analysis</topic><topic>Follow-Up Studies</topic><topic>Fysiologi och anatomi</topic><topic>Health risk assessment</topic><topic>Humans</topic><topic>Longitudinal Studies</topic><topic>Medicine</topic><topic>Obesity</topic><topic>Obesity - pathology</topic><topic>Physiology and Anatomy</topic><topic>Prospective Studies</topic><topic>pulse-wave velocity</topic><topic>Stiffening</topic><topic>Stiffness</topic><topic>Teenagers</topic><topic>Tunica Intima - pathology</topic><topic>Ultrasound</topic><topic>Vascular Stiffness - physiology</topic><topic>Veins & arteries</topic><topic>wall thickness</topic><topic>Wave velocity</topic><topic>young finns</topic><topic>Youth</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dangardt, Frida</creatorcontrib><creatorcontrib>Chen, Yun</creatorcontrib><creatorcontrib>Berggren, Krister</creatorcontrib><creatorcontrib>Osika, Walter</creatorcontrib><creatorcontrib>Friberg, Peter</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>SWEPUB Göteborgs universitet full text</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Freely available online</collection><collection>SWEPUB Göteborgs universitet</collection><collection>SwePub Articles full text</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dangardt, Frida</au><au>Chen, Yun</au><au>Berggren, Krister</au><au>Osika, Walter</au><au>Friberg, Peter</au><au>Kirchmair, Rudolf</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increased rate of arterial stiffening with obesity in adolescents: a five-year follow-up study</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2013-02-22</date><risdate>2013</risdate><volume>8</volume><issue>2</issue><spage>e57454</spage><epage>e57454</epage><pages>e57454-e57454</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>We prospectively and longitudinally determined the effects of childhood obesity on arterial stiffening and vascular wall changes. Changes in arterial stiffness measured as pulse wave velocity (PWV) and vascular morphology of the radial (RA) and dorsal pedal arteries (DPA) were examined in obese adolescents compared to lean subjects in a 5-year follow-up study.
A total of 28 obese subjects and 14 lean controls participated in both baseline (14 years old) and follow-up studies. PWV was measured by tonometer (SphygmoCor®) and recorded at RA and carotid artery, respectively. Intima thickness (IT), intima-media thickness (IMT) and RA and DPA diameters were measured using high-resolution ultrasound (Vevo 770™). Over the course of 5 years, PWV increased by 25% in the obese subjects as compared to 3% in the controls (p = 0.01). Diastolic blood pressure (DBP) increased by 23% in the obese subjects as opposed to 6% in controls (p = 0.009). BMI increased similarly in both groups, as did the IT and IMT. The change in PWV was strongly associated to the baseline BMI z -score (r = 0.51, p<0.001), as was the change in DBP (r = 0.50, p = 0.001).
During the transition from early to late adolescence, there was a general increase in arterial stiffness, which was aggravated by childhood obesity. The increase in arterial stiffness and DBP after 5 years was closely correlated to the baseline BMI z -score, indicating that childhood obesity has an adverse impact on vascular adaptation.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>23451232</pmid><doi>10.1371/journal.pone.0057454</doi><tpages>e57454</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Adolescent obesity Adolescents all-cause Arteries Blood Flow Velocity - physiology Blood pressure Body mass Body mass index cardiovascular risk-factors Carotid Arteries - pathology Carotid artery Case-Control Studies childhood Childhood obesity Children Comparative analysis Follow-Up Studies Fysiologi och anatomi Health risk assessment Humans Longitudinal Studies Medicine Obesity Obesity - pathology Physiology and Anatomy Prospective Studies pulse-wave velocity Stiffening Stiffness Teenagers Tunica Intima - pathology Ultrasound Vascular Stiffness - physiology Veins & arteries wall thickness Wave velocity young finns Youth |
| title | Increased rate of arterial stiffening with obesity in adolescents: a five-year follow-up study |
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