Safety and immunogenicity of neonatal pneumococcal conjugate vaccination in Papua New Guinean children: a randomised controlled trial

Approximately 826,000 children, mostly young infants, die annually from invasive pneumococcal disease. A 6-10-14-week schedule of pneumococcal conjugate vaccine (PCV) is efficacious but neonatal PCV may provide earlier protection and better coverage. We conducted an open randomized controlled trial...

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Veröffentlicht in:	PloS one 2013-02, Vol.8 (2), p.e56698
Hauptverfasser:	Pomat, William S, van den Biggelaar, Anita H J, Phuanukoonnon, Suparat, Francis, Jacinta, Jacoby, Peter, Siba, Peter M, Alpers, Michael P, Reeder, John C, Holt, Patrick G, Richmond, Peter C, Lehmann, Deborah
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Background levels Baseline studies Birth Children Children & youth Childrens health Clinical trials Disease Female Humans Immunization Schedule Immunogenicity Immunoglobulin G Immunoglobulin G - blood Immunology Infant Infant, Newborn Infants Male Medical research Medicine Meningitis Mortality Neonates Newborn babies Newborn infants Pneumococcal Infections - immunology Pneumococcal Infections - prevention & control Pneumococcal Vaccines - adverse effects Pneumococcal Vaccines - therapeutic use Pneumonia Polysaccharides Priming Randomization Safety Serotypes Streptococcus infections Vaccination Vaccines Vaccines, Conjugate - adverse effects Vaccines, Conjugate - therapeutic use
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