Reactive oxygen species via redox signaling to PI3K/AKT pathway contribute to the malignant growth of 4-hydroxy estradiol-transformed mammary epithelial cells

The purpose of this study was to investigate the effects of 17-β-estradiol (E2)-induced reactive oxygen species (ROS) on the induction of mammary tumorigenesis. We found that ROS-induced by repeated exposures to 4-hydroxy-estradiol (4-OH-E2), a predominant catechol metabolite of E2, caused transform...

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Veröffentlicht in:	PloS one 2013-02, Vol.8 (2), p.e54206
Hauptverfasser:	Okoh, Victor O, Felty, Quentin, Parkash, Jai, Poppiti, Robert, Roy, Deodutta
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase 17β-Estradiol Activation AKT protein Animals Azoles - pharmacology Biology Breast Breast cancer Catalase Catalase - metabolism Catechin Catechol Catechols - metabolism Cdc2 protein Cell cycle Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism Cell Proliferation - drug effects Cell Transformation, Neoplastic - drug effects Cell Transformation, Neoplastic - pathology Cellular signal transduction Collagen - pharmacology Colony-Forming Units Assay Dose-Response Relationship, Drug Epithelial cells Epithelial Cells - enzymology Epithelial Cells - pathology Estradiol Estradiol - analogs & derivatives Estradiol - pharmacology Estrogens Estrogens, Catechol - pharmacology Fulvestrant Gene expression Gene Expression Regulation, Neoplastic - drug effects Genes Genetic transformation Growth Humans Isoindoles Kinases Lesions Mammary gland Mammary Glands, Human - drug effects Mammary Glands, Human - enzymology Mammary Glands, Human - pathology Medicine Metabolites Mice Models, Biological Neoplasm Invasiveness Organoselenium Compounds - pharmacology Oxidation-Reduction - drug effects Oxygen Phenotype Phosphatidylinositol 3-Kinases - metabolism Phosphorylation Proliferating cell nuclear antigen Proto-Oncogene Proteins c-akt - metabolism Reactive oxygen species Reactive Oxygen Species - metabolism Ribonucleic acid RNA RNA-mediated interference Sex hormones Signal processing Signal transduction Signal Transduction - drug effects Signal Transduction - genetics Signaling Spheroids, Cellular - drug effects Spheroids, Cellular - metabolism Spheroids, Cellular - pathology Transcription factors Transformation Tumorigenesis Xenografts
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