Maternal low-protein diet affects epigenetic regulation of hepatic mitochondrial DNA transcription in a sex-specific manner in newborn piglets associated with GR binding to its promoter

Mitochondrial oxidative phosphorylation (OXPHOS) plays an important role in energy homeostasis by controlling electron transfer and ATP generation. Maternal malnutrition during pregnancy affects mitochondrial (mt) DNA-encoded OXPHOS activity in offspring, yet it is unknown whether epigenetic mechani...

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Veröffentlicht in:	PloS one 2013-05, Vol.8 (5), p.e63855
Hauptverfasser:	Jia, Yimin, Li, Runsheng, Cong, Rihua, Yang, Xiaojing, Sun, Qinwei, Parvizi, Nahid, Zhao, Ruqian
Format:	Artikel
Sprache:	eng
Schlagworte:	5-Methylcytosine - metabolism Agriculture AMP Analysis Animals Animals, Newborn Binding Biochemistry Biology Copy number Cytochrome Cytochrome b Cytochrome-c oxidase Cytochromes Cytosine Cytosine - analogs & derivatives Cytosine - metabolism Deoxyribonucleic acid Diabetes Diet Dietary Proteins - pharmacology DNA DNA methylation DNA Methylation - drug effects DNA, Mitochondrial - genetics Electron transfer Electron transport Electron Transport Complex IV - genetics Electron Transport Complex IV - metabolism Energy balance Energy charge Enzymatic activity Enzyme activity Epigenesis, Genetic - drug effects Epigenetic inheritance Female Females Gene expression Gene regulation Genes Genetic research Genomes Genomics Gestation Glucocorticoids Homeostasis Hormones Laboratories Liver Liver - metabolism Low protein diet Male Males Malnutrition Mammals Medicine Metabolic syndrome Methylation Mitochondria Mitochondrial DNA Mothers Musculoskeletal system NADH NADH dehydrogenase Nicotinamide adenine dinucleotide Nutrition Offspring Oxidase Oxidases Oxidative phosphorylation Phosphorylation Physiology Pregnancy Promoter Regions, Genetic - drug effects Promoter Regions, Genetic - genetics Protein Binding - drug effects Proteins Pyrimidines Receptors, Glucocorticoid - metabolism RNA RNA, Messenger - genetics RNA, Messenger - metabolism Rodents Sex Sex Characteristics Swine Systematic review Transcription Transcription (Genetics) Transcription, Genetic - drug effects Veterinary Science
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