Methylselenol formed by spontaneous methylation of selenide is a superior selenium substrate to the thioredoxin and glutaredoxin systems

Naturally occurring selenium compounds like selenite and selenodiglutathione are metabolized to selenide in plants and animals. This highly reactive form of selenium can undergo methylation and form monomethylated and multimethylated species. These redox active selenium metabolites are of particular...

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Veröffentlicht in:	PloS one 2012-11, Vol.7 (11), p.e50727
Hauptverfasser:	Fernandes, Aristi P, Wallenberg, Marita, Gandin, Valentina, Misra, Sougat, Tisato, Francesco, Marzano, Cristina, Rigobello, Maria Pia, Kumar, Sushil, Björnstedt, Mikael
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosylmethionine Anticancer properties Antineoplastic Agents - metabolism Antineoplastic Agents - pharmacology Apoptosis Biological Transport Biology Cancer Cell cycle Cell Line, Tumor Cell Survival - drug effects Chemistry Cytochromes c - metabolism Cytotoxicity Deoxyribonucleic acid Disulfides - metabolism DNA DNA methylation Glutaredoxin Glutaredoxins - metabolism Glutathione - analogs & derivatives Glutathione - metabolism Gypsum Humans Intracellular Space - metabolism Kinases Laboratories Mammals Medicine Metabolism Metabolites Methanol - analogs & derivatives Methanol - metabolism Methanol - pharmacology Methylation Oncorhynchus mykiss Organoselenium Compounds - metabolism Organoselenium Compounds - pharmacology Oxidation-Reduction Oxidative stress Oxygen Pathology Pharmaceutical sciences Pharmacology Physiological aspects Physiological effects Plants (botany) Prostate cancer Protein Binding Proteins Redox properties S-Adenosylmethionine S-Adenosylmethionine - metabolism S-Adenosylmethionine - pharmacology Saccharomyces cerevisiae Selenide Selenite Selenium Selenium (Chemical element) Selenium compounds Selenium Compounds - metabolism Selenium Compounds - pharmacology Substrates Superoxides - metabolism Thiols Thioredoxin Thioredoxin-Disulfide Reductase - metabolism Thioredoxins Thioredoxins - metabolism Toxicity
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