Homeostatic tissue responses in skin biopsies from NOMID patients with constitutive overproduction of IL-1β

The autoinflammatory disorder, Neonatal-onset Multisystem Inflammatory Disease (NOMID) is the most severe phenotype of disorders caused by mutations in CIAS1 that result in increased production and secretion of active IL-1β. NOMID patients present with systemic and organ-specific inflammation of the...

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Veröffentlicht in:	PloS one 2012-11, Vol.7 (11), p.e49408
Hauptverfasser:	Aubert, Pamela, Suárez-Fariñas, Mayte, Mitsui, Hiroshi, Johnson-Huang, Leanne M, Harden, Jamie Lynn, Pierson, Katherine C, Dolan, Joseph G, Novitskaya, Inna, Coats, Israel, Estes, Jacob, Cowen, Edward W, Plass, Nicole, Lee, Chyi-Chia Richard, Sun, Hong-Wei, Lowes, Michelle A, Goldbach-Mansky, Raphaela
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptive control Adolescent Adult Antigen presentation Antigens, CD - genetics Antigens, CD - immunology Biology Biopsy Caspase Caspase 1 - genetics Caspase 1 - immunology Caspase-1 CCL20 protein CD11c antigen CD163 antigen CD3 antigen Central nervous system Child Child, Preschool Cryopyrin-Associated Periodic Syndromes - drug therapy Cryopyrin-Associated Periodic Syndromes - genetics Cryopyrin-Associated Periodic Syndromes - immunology Cryopyrin-Associated Periodic Syndromes - pathology Cytokines Defensins Dendritic cells Dermatology Disease Epigenesis, Genetic - drug effects Epigenesis, Genetic - immunology Epigenetics Female Gene expression Gene Expression - drug effects Gene Expression - immunology Genes Genotype & phenotype Histocompatibility antigen HLA HLA-DR Antigens - genetics HLA-DR Antigens - immunology Homeostasis Homeostasis - drug effects Homeostasis - genetics Homeostasis - immunology Humans Inflammation Inflammatory diseases Interleukin 1 Interleukin 1 receptor antagonist Interleukin 1 Receptor Antagonist Protein - pharmacology Interleukin 1 Receptor Antagonist Protein - therapeutic use Interleukin 6 Interleukin 8 Interleukin-1beta - antagonists & inhibitors Interleukin-1beta - genetics Interleukin-1beta - immunology Laboratories Langerhans Cells - drug effects Langerhans Cells - immunology Langerhans Cells - pathology Leukocytes (neutrophilic) Lymphocytes Lymphocytes T Macrophages Macrophages - drug effects Macrophages - immunology Macrophages - pathology Male Medicine MicroRNAs - genetics MicroRNAs - immunology Mutation Neonates Neutrophils Neutrophils - drug effects Neutrophils - immunology Neutrophils - pathology Patients Psoriasis Receptors, Interleukin-1 - antagonists & inhibitors Receptors, Interleukin-1 - genetics Receptors, Interleukin-1 - immunology Signal transduction Signal Transduction - drug effects Signaling Skin Skin - drug effects Skin - immunology Skin - pathology Skin diseases T-Lymphocytes - drug effects T-Lymphocytes - immunology T-Lymphocytes - pathology Tissues
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