Insulin-like growth factor-1 signaling regulates miRNA expression in MCF-7 breast cancer cell line

In breast carcinomas, increased levels of insulin-like growth factor 1 (IGF-1) can act as a mitogen to augment tumorigenesis through the regulation of MAPK and AKT signaling pathways. Signaling through these two pathways allows IGF-1 to employ mechanisms that favor proliferation and cellular surviva...

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Veröffentlicht in:	PloS one 2012-11, Vol.7 (11), p.e49067
Hauptverfasser:	Martin, Elizabeth C, Bratton, Melyssa R, Zhu, Yun, Rhodes, Lyndsay V, Tilghman, Syreeta L, Collins-Burow, Bridgette M, Burow, Matthew E
Format:	Artikel
Sprache:	eng
Schlagworte:	AKT protein Apoptosis Biology Breast cancer Breast carcinoma Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - pathology Cancer Carcinoma - genetics Carcinoma - metabolism Carcinoma - pathology Cell cycle Cell growth Cell Line, Tumor Cell Proliferation - drug effects Cell survival Cell Survival - drug effects Estrogens Female Gastric cancer Gene expression Gene Expression Profiling Gene Expression Regulation, Neoplastic - drug effects Hematology Humans Insulin Insulin-like growth factor I Insulin-Like Growth Factor I - genetics Insulin-Like Growth Factor I - metabolism Insulin-Like Growth Factor I - pharmacology Insulin-like growth factors Kinases Liver cancer MAP kinase Medical research Medicine Metastasis MicroRNA MicroRNAs MicroRNAs - genetics MicroRNAs - metabolism miRNA Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors Mitogen-Activated Protein Kinase Kinases - genetics Mitogen-Activated Protein Kinase Kinases - metabolism Oligonucleotide Array Sequence Analysis Oncology Pathways Protein Kinase Inhibitors - pharmacology Proteins Proto-Oncogene Proteins c-akt - antagonists & inhibitors Proto-Oncogene Proteins c-akt - genetics Proto-Oncogene Proteins c-akt - metabolism Real-Time Polymerase Chain Reaction Signal transduction Signal Transduction - drug effects Signaling Stomach cancer Tumor suppressor genes Tumorigenesis
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