Relationship between circulating and tissue microRNAs in a murine model of breast cancer

MiRNAs are key regulators of tumorigenesis that are aberrantly expressed in the circulation and tissue of patients with cancer. The aim of this study was to determine whether miRNA dysregulation in the circulation reflected similar changes in tumour tissue. Athymic nude mice (n = 20) received either...

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Veröffentlicht in:	PloS one 2012-11, Vol.7 (11), p.e50459-e50459
Hauptverfasser:	Waters, Peadar S, McDermott, Ailbhe M, Wall, Deirdre, Heneghan, Helen M, Miller, Nicola, Newell, John, Kerin, Michael J, Dwyer, Roisin M
Format:	Artikel
Sprache:	eng
Schlagworte:	Aberration Animal models Animals Applied mathematics Bioindicators Biology Biomarkers Biomarkers, Tumor - blood Biomarkers, Tumor - genetics Blood tests Breast cancer Breast Neoplasms - blood Breast Neoplasms - diagnosis Breast Neoplasms - genetics Breast Neoplasms - pathology Cancer Cancer research Cell cycle Cell Line, Tumor Circulation Colorectal cancer Discipline Disease Disease Models, Animal Disease Progression Female Fluorides Gastric cancer Gene expression Gene Expression Profiling Gene Expression Regulation, Neoplastic Humans Injections, Subcutaneous Lung - metabolism Lung - pathology Lungs Lymph nodes Lymph Nodes - metabolism Lymph Nodes - pathology Mammography Medical prognosis Medicine Metastasis Mice Mice, Nude MicroRNA MicroRNAs MicroRNAs - blood MicroRNAs - genetics miRNA Neoplasm Transplantation Prostate cancer Proteins Regulators Stomach cancer Studies Surgery Tissues Tumor Burden Tumorigenesis Tumors
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