Robo4 plays a role in bone marrow homing and mobilization, but is not essential in the long-term repopulating capacity of hematopoietic stem cells

Roundabout (Robo) family proteins are immunoglobulin-type surface receptors critical for cellular migration and pathway finding of neuronal axons. We have previously shown that Robo4 was specifically expressed in hematopoietic stem and progenitor cells and its high expression correlated with long-te...

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Veröffentlicht in:	PloS one 2012-11, Vol.7 (11), p.e50849-e50849
Hauptverfasser:	Goto-Koshino, Yuko, Fukuchi, Yumi, Shibata, Fumi, Abe, Daichi, Kuroda, Kana, Okamoto, Shinichiro, Kitamura, Toshio, Nakajima, Hideaki
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Animals Axons Biology Blood Blood Cell Count Blood cells Bone marrow Bone Marrow Cells - cytology Bone Marrow Cells - drug effects Bone Marrow Cells - metabolism Cell cycle Cell differentiation Cell self-renewal Cells (biology) Colony-stimulating factor Competition Engraftment Experiments Genotype & phenotype Granulocyte Colony-Stimulating Factor - pharmacology Hematology Hematopoiesis Hematopoiesis - drug effects Hematopoietic Stem Cell Mobilization Hematopoietic stem cells Hematopoietic Stem Cells - cytology Hematopoietic Stem Cells - drug effects Hematopoietic Stem Cells - metabolism Homing Homing behavior Immunoglobulins Internal medicine Leukocytes (granulocytic) Medicine Mice Mice, Inbred C57BL Mice, Mutant Strains Nerve Tissue Proteins - metabolism Neural stem cells Physiological effects Population Proteins Receptors Receptors, Immunologic - metabolism Robo protein Rodents Stem cell transplantation Stem cells Transplantation
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