The LEGSKO mouse: a mouse model of age-related nuclear cataract based on genetic suppression of lens glutathione synthesis

Age-related nuclear cataracts are associated with progressive post-synthetic modifications of crystallins from various physical chemical and metabolic insults, of which oxidative stress is a major factor. The latter is normally suppressed by high concentrations of glutathione (GSH), which however ar...

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Veröffentlicht in:	PloS one 2012-11, Vol.7 (11), p.e50832
Hauptverfasser:	Fan, Xingjun, Liu, Xiaoqin, Hao, Shuyu, Wang, Benlian, Robinson, Michael L, Monnier, Vincent M
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Aging Aging - pathology Amino acids Analysis Animals Biochemistry Biology Cataract - enzymology Cataract - pathology Cataracts Chemistry Cortex Crystal structure Crystallin Crystallinity Disease Models, Animal DNA - metabolism Gene Deletion Genetic engineering Genetic suppression Genotype Glutamate-Cysteine Ligase - deficiency Glutamate-Cysteine Ligase - genetics Glutamate-Cysteine Ligase - metabolism Glutathione Glutathione - biosynthesis Glycosylation Homeostasis Humans Lens Nucleus, Crystalline - enzymology Lens Nucleus, Crystalline - pathology Lenses Mass spectrometry Medicine Methionine Mice Mice, Inbred C57BL Mice, Knockout Nuclei Oxidation Oxidative stress Oxidizing agents Pathology Phenotype Proteins Pyruvaldehyde Reactive Oxygen Species - metabolism Rodents Scientific imaging Suppression, Genetic Synthesis Thiols Transgenic mice
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