Cytosolic, autocrine alpha-1 proteinase inhibitor (A1PI) inhibits caspase-1 and blocks IL-1β dependent cytokine release in monocytes

Activation state-dependent secretion of alpha-1 proteinase inhibitor (A1PI) by monocytes and macrophages was first reported in 1985. Since then, monocytes and tissue macrophages have emerged as key sentinels of infection and tissue damage via activation of self-assembling pattern recognition recepto...

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Veröffentlicht in:	PloS one 2012-11, Vol.7 (11), p.e51078-e51078
Hauptverfasser:	Wang, Yonggang, He, Yong, Abraham, Bindu, Rouhani, Farshid N, Brantly, Mark L, Scott, Dorothy E, Reed, Jennifer L
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation alpha 1-Antitrypsin - metabolism Apoptosis Augmentation Autocrine Communication Autocrine signalling Biology Caspase Caspase 1 - metabolism Caspase-1 Cell activation Cell death Cell lines Cells, Cultured Childrens health Consent Cystic fibrosis Cytokines Cytosol - metabolism Diabetes Disease control Emphysema Endoplasmic reticulum Expression vectors FDA approval Food Glycosylation Human subjects Humans Immunoprecipitation Infections Inflammasomes Inflammation Influenza Inhibition Inhibitors Interleukin 1 Interleukin-1beta - secretion Kinases Localization Lung - metabolism Lung diseases Macrophages Medicine Monocytes Monocytes - drug effects Monocytes - metabolism Nigericin Pathogens Pattern recognition Pattern recognition receptors Protein Binding Proteinase Proteinase inhibitors Proteins Receptors Substrates Titration Transfection Tumor necrosis factor-α
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