Proinflammatory cytokine response and viral replication in mouse bone marrow derived macrophages infected with influenza H1N1 and H5N1 viruses

The pathogenesis of human influenza H5N1 virus infection remains poorly understood and controversial. Cytokine dysregulation in human infection has been hypothesized to contribute to disease severity. We developed in vitro cultures of mouse bone marrow derived macrophages (BMDMΦ) from C57BL/6N mouse...

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Veröffentlicht in:	PloS one 2012-11, Vol.7 (11), p.e51057-e51057
Hauptverfasser:	Chan, Renee W Y, Leung, Connie Y H, Nicholls, John M, Peiris, J S Malik, Chan, Michael C W
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animals Avian influenza Avian influenza viruses Biology Bone marrow Chemokines - genetics Chemokines - metabolism Cytokines Cytokines - genetics Cytokines - metabolism Cytokines - secretion Female Fluorescent Antibody Technique Gene Expression Regulation Health aspects Humans Infection Infections Inflammation Inflammation Mediators - metabolism Influenza Influenza A Influenza A Virus, H1N1 Subtype - physiology Influenza A Virus, H5N1 Subtype - physiology Influenza, Human - virology IP-10 protein Lectins - metabolism Macrophages Macrophages - immunology Macrophages - pathology Macrophages - secretion Macrophages - virology Medicine Mice Mice, Inbred C57BL Orthomyxoviridae Infections - immunology Orthomyxoviridae Infections - pathology Orthomyxoviridae Infections - virology Pandemics Pathogenesis Replication Studies Swine flu Tumor necrosis factor-TNF Tumor necrosis factor-α Viral Load Viral Matrix Proteins - genetics Viral Matrix Proteins - metabolism Virus replication Virus Replication - physiology Viruses
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