Aberrant functional organization within and between resting-state networks in AD
Altered functional characteristics have been reported in amnestic mild cognitive impairment (aMCI) and Alzheimer's disease (AD); nonetheless, comprehensive analyses of the resting-state networks (RSNs) are rare. This study combined multiple imaging modalities to investigate the functional and s...
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| description | Altered functional characteristics have been reported in amnestic mild cognitive impairment (aMCI) and Alzheimer's disease (AD); nonetheless, comprehensive analyses of the resting-state networks (RSNs) are rare. This study combined multiple imaging modalities to investigate the functional and structural changes within each RSN and between RSNs in aMCI/AD patients. Eight RSNs were identified from functional MRI data from 35 AD, 18 aMCI and 21 normal control subjects using independent component analysis. We compared functional connectivity (FC) within each RSN and found decreased FC in the several cognitive-related RSNs in AD, including the bilateral precuneus of the precuneus network, the posterior cingulate cortex and left precuneus of the posterior default mode network (DMN), and the left superior parietal lobule of the left frontoparietal network (LFP). We further compared the grey matter volumes and amplitudes of low-frequency fluctuations of these regions and found decreases in these measures in AD. Importantly, we found decreased inter-network connectivity between the visual network and the LFP and between the anterior and posterior DMNs in AD. All indices in aMCI patients were numerically between those of controls and AD patients. These results suggest that the brain networks supporting complex cognitive processes are specifically and progressively impaired over the course of AD, and the FC impairments are present not only within networks but also between networks. |
| doi_str_mv | 10.1371/journal.pone.0063727 |
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This study combined multiple imaging modalities to investigate the functional and structural changes within each RSN and between RSNs in aMCI/AD patients. Eight RSNs were identified from functional MRI data from 35 AD, 18 aMCI and 21 normal control subjects using independent component analysis. We compared functional connectivity (FC) within each RSN and found decreased FC in the several cognitive-related RSNs in AD, including the bilateral precuneus of the precuneus network, the posterior cingulate cortex and left precuneus of the posterior default mode network (DMN), and the left superior parietal lobule of the left frontoparietal network (LFP). We further compared the grey matter volumes and amplitudes of low-frequency fluctuations of these regions and found decreases in these measures in AD. Importantly, we found decreased inter-network connectivity between the visual network and the LFP and between the anterior and posterior DMNs in AD. All indices in aMCI patients were numerically between those of controls and AD patients. These results suggest that the brain networks supporting complex cognitive processes are specifically and progressively impaired over the course of AD, and the FC impairments are present not only within networks but also between networks.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0063727</identifier><identifier>PMID: 23667665</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Aberration ; Advertising executives ; Aged ; Alzheimer Disease - pathology ; Alzheimer Disease - physiopathology ; Alzheimer's disease ; Automation ; Biology ; Brain ; Brain Mapping ; Cerebral Cortex - pathology ; Cerebral Cortex - physiopathology ; Cognitive ability ; Comparative analysis ; Cortex (cingulate) ; Cortex (parietal) ; Dementia ; Demography ; Family medical history ; Female ; Functional magnetic resonance imaging ; Functional morphology ; Humans ; Independent component analysis ; Laboratories ; Male ; Medical research ; Medicine ; Memory ; Nerve Net - pathology ; Nerve Net - physiopathology ; Networks ; Neural networks ; Neurodegenerative diseases ; Neuroimaging ; Neurology ; Neurophysiology ; Neuropsychological Tests ; Neurosciences ; Older people ; Organ Size ; Patients ; Pattern recognition ; Rest - physiology ; Structure-function relationships ; Substantia grisea ; Superior parietal lobule ; Visual cortex</subject><ispartof>PloS one, 2013-05, Vol.8 (5), p.e63727</ispartof><rights>COPYRIGHT 2013 Public Library of Science</rights><rights>2013 Song et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2013 Song et al 2013 Song et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-fa3930d2304d57c7b38925471cc2470f676a5bda619b3042d7a52f51279d37f03</citedby><cites>FETCH-LOGICAL-c692t-fa3930d2304d57c7b38925471cc2470f676a5bda619b3042d7a52f51279d37f03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3647055/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3647055/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,865,886,2103,2929,23871,27929,27930,53796,53798</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23667665$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Chen, Kewei</contributor><creatorcontrib>Song, Jinyu</creatorcontrib><creatorcontrib>Qin, Wen</creatorcontrib><creatorcontrib>Liu, Yong</creatorcontrib><creatorcontrib>Duan, Yunyun</creatorcontrib><creatorcontrib>Liu, Jieqiong</creatorcontrib><creatorcontrib>He, Xiaoxi</creatorcontrib><creatorcontrib>Li, Kuncheng</creatorcontrib><creatorcontrib>Zhang, Xinqing</creatorcontrib><creatorcontrib>Jiang, Tianzi</creatorcontrib><creatorcontrib>Yu, Chunshui</creatorcontrib><title>Aberrant functional organization within and between resting-state networks in AD</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Altered functional characteristics have been reported in amnestic mild cognitive impairment (aMCI) and Alzheimer's disease (AD); nonetheless, comprehensive analyses of the resting-state networks (RSNs) are rare. This study combined multiple imaging modalities to investigate the functional and structural changes within each RSN and between RSNs in aMCI/AD patients. Eight RSNs were identified from functional MRI data from 35 AD, 18 aMCI and 21 normal control subjects using independent component analysis. We compared functional connectivity (FC) within each RSN and found decreased FC in the several cognitive-related RSNs in AD, including the bilateral precuneus of the precuneus network, the posterior cingulate cortex and left precuneus of the posterior default mode network (DMN), and the left superior parietal lobule of the left frontoparietal network (LFP). We further compared the grey matter volumes and amplitudes of low-frequency fluctuations of these regions and found decreases in these measures in AD. Importantly, we found decreased inter-network connectivity between the visual network and the LFP and between the anterior and posterior DMNs in AD. All indices in aMCI patients were numerically between those of controls and AD patients. These results suggest that the brain networks supporting complex cognitive processes are specifically and progressively impaired over the course of AD, and the FC impairments are present not only within networks but also between networks.</description><subject>Aberration</subject><subject>Advertising executives</subject><subject>Aged</subject><subject>Alzheimer Disease - pathology</subject><subject>Alzheimer Disease - physiopathology</subject><subject>Alzheimer's disease</subject><subject>Automation</subject><subject>Biology</subject><subject>Brain</subject><subject>Brain Mapping</subject><subject>Cerebral Cortex - pathology</subject><subject>Cerebral Cortex - physiopathology</subject><subject>Cognitive ability</subject><subject>Comparative analysis</subject><subject>Cortex (cingulate)</subject><subject>Cortex (parietal)</subject><subject>Dementia</subject><subject>Demography</subject><subject>Family medical history</subject><subject>Female</subject><subject>Functional magnetic resonance imaging</subject><subject>Functional morphology</subject><subject>Humans</subject><subject>Independent component analysis</subject><subject>Laboratories</subject><subject>Male</subject><subject>Medical research</subject><subject>Medicine</subject><subject>Memory</subject><subject>Nerve Net - pathology</subject><subject>Nerve Net - physiopathology</subject><subject>Networks</subject><subject>Neural networks</subject><subject>Neurodegenerative diseases</subject><subject>Neuroimaging</subject><subject>Neurology</subject><subject>Neurophysiology</subject><subject>Neuropsychological Tests</subject><subject>Neurosciences</subject><subject>Older people</subject><subject>Organ Size</subject><subject>Patients</subject><subject>Pattern recognition</subject><subject>Rest - physiology</subject><subject>Structure-function relationships</subject><subject>Substantia grisea</subject><subject>Superior parietal lobule</subject><subject>Visual cortex</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNkltv0zAYhiMEYmPwDxBEQkJw0eJDfMgNUrVxqDRpiNOt5dhO65Lane1swK_HodnUoF2gXCT5_Hzvd_BbFE8hmEPM4JuN74OT3XznnZkDQDFD7F5xDGuMZhQBfP_g-6h4FOMGAII5pQ-LI4QpZZSS4-LTojEhSJfKtncqWZ8lSx9W0tnfcvgtr21aW1dKp8vGpGtjXBlMTNatZjHJZEqXoz78iGWmFmePiwet7KJ5Mr5Pim_v3309_Tg7v_iwPF2czxStUZq1EtcYaIRBpQlTrMG8RqRiUClUMdDm9iRptKSwbjKDNJMEtQQiVmvMWoBPiud73V3noxiXEQXEBNSUcw4zsdwT2suN2AW7leGX8NKKv4E8pJAhWdUZQaBGNSa1YppVBuqm4QoglJsEiHAwaL0dq_XN1mhlXAqym4hOT5xdi5W_EpjmaQjJAq9GgeAv-7w_sbVRma6Tzvh-3zevK4CGWi_-Qe-ebqRWMg9gXetzXTWIikXFeN4u5yxT8zuo_GiztSo7p7U5Pkl4PUnITDI_00r2MYrll8__z158n7IvD9i1kV1aR9_1g8XiFKz2oAo-xmDa2yVDIAbj32xDDMYXo_Fz2rPDC7pNunE6_gMH9Pxl</recordid><startdate>20130507</startdate><enddate>20130507</enddate><creator>Song, Jinyu</creator><creator>Qin, Wen</creator><creator>Liu, Yong</creator><creator>Duan, Yunyun</creator><creator>Liu, Jieqiong</creator><creator>He, Xiaoxi</creator><creator>Li, Kuncheng</creator><creator>Zhang, Xinqing</creator><creator>Jiang, Tianzi</creator><creator>Yu, Chunshui</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20130507</creationdate><title>Aberrant functional organization within and between resting-state networks in AD</title><author>Song, Jinyu ; Qin, Wen ; Liu, Yong ; Duan, Yunyun ; Liu, Jieqiong ; He, Xiaoxi ; Li, Kuncheng ; Zhang, Xinqing ; Jiang, Tianzi ; Yu, Chunshui</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-fa3930d2304d57c7b38925471cc2470f676a5bda619b3042d7a52f51279d37f03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Aberration</topic><topic>Advertising executives</topic><topic>Aged</topic><topic>Alzheimer Disease - pathology</topic><topic>Alzheimer Disease - physiopathology</topic><topic>Alzheimer's disease</topic><topic>Automation</topic><topic>Biology</topic><topic>Brain</topic><topic>Brain Mapping</topic><topic>Cerebral Cortex - pathology</topic><topic>Cerebral Cortex - physiopathology</topic><topic>Cognitive ability</topic><topic>Comparative analysis</topic><topic>Cortex (cingulate)</topic><topic>Cortex (parietal)</topic><topic>Dementia</topic><topic>Demography</topic><topic>Family medical history</topic><topic>Female</topic><topic>Functional magnetic resonance imaging</topic><topic>Functional morphology</topic><topic>Humans</topic><topic>Independent component analysis</topic><topic>Laboratories</topic><topic>Male</topic><topic>Medical research</topic><topic>Medicine</topic><topic>Memory</topic><topic>Nerve Net - pathology</topic><topic>Nerve Net - physiopathology</topic><topic>Networks</topic><topic>Neural networks</topic><topic>Neurodegenerative diseases</topic><topic>Neuroimaging</topic><topic>Neurology</topic><topic>Neurophysiology</topic><topic>Neuropsychological Tests</topic><topic>Neurosciences</topic><topic>Older people</topic><topic>Organ Size</topic><topic>Patients</topic><topic>Pattern recognition</topic><topic>Rest - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Song, Jinyu</au><au>Qin, Wen</au><au>Liu, Yong</au><au>Duan, Yunyun</au><au>Liu, Jieqiong</au><au>He, Xiaoxi</au><au>Li, Kuncheng</au><au>Zhang, Xinqing</au><au>Jiang, Tianzi</au><au>Yu, Chunshui</au><au>Chen, Kewei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Aberrant functional organization within and between resting-state networks in AD</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2013-05-07</date><risdate>2013</risdate><volume>8</volume><issue>5</issue><spage>e63727</spage><pages>e63727-</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Altered functional characteristics have been reported in amnestic mild cognitive impairment (aMCI) and Alzheimer's disease (AD); nonetheless, comprehensive analyses of the resting-state networks (RSNs) are rare. This study combined multiple imaging modalities to investigate the functional and structural changes within each RSN and between RSNs in aMCI/AD patients. Eight RSNs were identified from functional MRI data from 35 AD, 18 aMCI and 21 normal control subjects using independent component analysis. We compared functional connectivity (FC) within each RSN and found decreased FC in the several cognitive-related RSNs in AD, including the bilateral precuneus of the precuneus network, the posterior cingulate cortex and left precuneus of the posterior default mode network (DMN), and the left superior parietal lobule of the left frontoparietal network (LFP). We further compared the grey matter volumes and amplitudes of low-frequency fluctuations of these regions and found decreases in these measures in AD. Importantly, we found decreased inter-network connectivity between the visual network and the LFP and between the anterior and posterior DMNs in AD. All indices in aMCI patients were numerically between those of controls and AD patients. These results suggest that the brain networks supporting complex cognitive processes are specifically and progressively impaired over the course of AD, and the FC impairments are present not only within networks but also between networks.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>23667665</pmid><doi>10.1371/journal.pone.0063727</doi><tpages>e63727</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2013-05, Vol.8 (5), p.e63727 |
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| language | eng |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Public Library of Science (PLoS) Journals Open Access; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Aberration Advertising executives Aged Alzheimer Disease - pathology Alzheimer Disease - physiopathology Alzheimer's disease Automation Biology Brain Brain Mapping Cerebral Cortex - pathology Cerebral Cortex - physiopathology Cognitive ability Comparative analysis Cortex (cingulate) Cortex (parietal) Dementia Demography Family medical history Female Functional magnetic resonance imaging Functional morphology Humans Independent component analysis Laboratories Male Medical research Medicine Memory Nerve Net - pathology Nerve Net - physiopathology Networks Neural networks Neurodegenerative diseases Neuroimaging Neurology Neurophysiology Neuropsychological Tests Neurosciences Older people Organ Size Patients Pattern recognition Rest - physiology Structure-function relationships Substantia grisea Superior parietal lobule Visual cortex |
| title | Aberrant functional organization within and between resting-state networks in AD |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-12T02%3A57%3A56IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Aberrant%20functional%20organization%20within%20and%20between%20resting-state%20networks%20in%20AD&rft.jtitle=PloS%20one&rft.au=Song,%20Jinyu&rft.date=2013-05-07&rft.volume=8&rft.issue=5&rft.spage=e63727&rft.pages=e63727-&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0063727&rft_dat=%3Cgale_plos_%3EA478393887%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1350968881&rft_id=info:pmid/23667665&rft_galeid=A478393887&rft_doaj_id=oai_doaj_org_article_51d29359c7d74e1dbb8c022fa3025801&rfr_iscdi=true |