Comprehensive investigation of the caveolin 2 gene: resequencing and association for kidney transplant outcomes

Caveolae are plasma membrane structures formed from a complex of the proteins caveolin-1 and caveolin-2. Caveolae interact with pro-inflammatory cytokines and are dysregulated in fibrotic disease. Although caveolae are present infrequently in healthy kidneys, they are abundant during kidney injury....

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Veröffentlicht in:	PloS one 2013-05, Vol.8 (5), p.e63358-e63358
Hauptverfasser:	McCaughan, Jennifer A, Duffy, Seamus, O'Hagan, Thomas, Courtney, Aisling E, Borrows, Richard, Conlon, Peter J, Maxwell, Alexander P, McKnight, Amy Jayne
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Analysis Biology Caveolae Caveolin Caveolin 2 - genetics Caveolin-1 Consent Cytokines Deoxyribonucleic acid Diabetes DNA Donors Ethics Female Fibroblasts Fibrosis Gene deletion Genes Genetic diversity Genetic testing Genetic variance Genomes Genotyping Genotyping Techniques Glaucoma Graft Survival - genetics Haplotypes - genetics Hospitals Humans Immunology Inflammation Insertion Investigations Ireland Kaplan-Meier Estimate Kidney diseases Kidney Transplantation Kidney transplants Kidneys Linkage Disequilibrium - genetics Male Medical prognosis Medical research Medicine Membrane structures Nephrology Polymorphism, Single Nucleotide - genetics Proportional Hazards Models Proteins Renal failure Reproducibility of Results Sequence Analysis, DNA Signal transduction Single nucleotide polymorphisms Single-nucleotide polymorphism Studies Survival Transplantation Transplants Transplants & implants Treatment Outcome Type 2 diabetes
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