Comprehensive investigation of the caveolin 2 gene: resequencing and association for kidney transplant outcomes
Caveolae are plasma membrane structures formed from a complex of the proteins caveolin-1 and caveolin-2. Caveolae interact with pro-inflammatory cytokines and are dysregulated in fibrotic disease. Although caveolae are present infrequently in healthy kidneys, they are abundant during kidney injury....
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| description | Caveolae are plasma membrane structures formed from a complex of the proteins caveolin-1 and caveolin-2. Caveolae interact with pro-inflammatory cytokines and are dysregulated in fibrotic disease. Although caveolae are present infrequently in healthy kidneys, they are abundant during kidney injury. An association has been identified between a CAV1 gene variant and long term kidney transplant survival. Chronic, gradual decline in transplant function is a persistent problem in kidney transplantation. The aetiology of this is diverse but fibrosis within the transplanted organ is the common end point. This study is the first to investigate the association of CAV2 gene variants with kidney transplant outcomes. Genomic DNA from donors and recipients of 575 kidney transplants performed in Belfast was investigated for common variation in CAV2 using a tag SNP approach. The CAV2 SNP rs13221869 was nominally significant for kidney transplant failure. Validation was sought in an independent group of kidney transplant donors and recipients from Dublin, Ireland using a second genotyping technology. Due to the unexpected absence of rs13221869 from this cohort, the CAV2 gene was resequenced. One novel SNP and a novel insertion/deletion in CAV2 were identified; rs13221869 is located in a repetitive region and was not a true variant in resequenced populations. CAV2 is a plausible candidate gene for association with kidney transplant outcomes given its proximity to CAV1 and its role in attenuating fibrosis. This study does not support an association between CAV2 variation and kidney transplant survival. Further analysis of CAV2 should be undertaken with an awareness of the sequence complexities and genetic variants highlighted by this study. |
| doi_str_mv | 10.1371/journal.pone.0063358 |
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Caveolae interact with pro-inflammatory cytokines and are dysregulated in fibrotic disease. Although caveolae are present infrequently in healthy kidneys, they are abundant during kidney injury. An association has been identified between a CAV1 gene variant and long term kidney transplant survival. Chronic, gradual decline in transplant function is a persistent problem in kidney transplantation. The aetiology of this is diverse but fibrosis within the transplanted organ is the common end point. This study is the first to investigate the association of CAV2 gene variants with kidney transplant outcomes. Genomic DNA from donors and recipients of 575 kidney transplants performed in Belfast was investigated for common variation in CAV2 using a tag SNP approach. The CAV2 SNP rs13221869 was nominally significant for kidney transplant failure. Validation was sought in an independent group of kidney transplant donors and recipients from Dublin, Ireland using a second genotyping technology. Due to the unexpected absence of rs13221869 from this cohort, the CAV2 gene was resequenced. One novel SNP and a novel insertion/deletion in CAV2 were identified; rs13221869 is located in a repetitive region and was not a true variant in resequenced populations. CAV2 is a plausible candidate gene for association with kidney transplant outcomes given its proximity to CAV1 and its role in attenuating fibrosis. This study does not support an association between CAV2 variation and kidney transplant survival. Further analysis of CAV2 should be undertaken with an awareness of the sequence complexities and genetic variants highlighted by this study.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0063358</identifier><identifier>PMID: 23667606</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Analysis ; Biology ; Caveolae ; Caveolin ; Caveolin 2 - genetics ; Caveolin-1 ; Consent ; Cytokines ; Deoxyribonucleic acid ; Diabetes ; DNA ; Donors ; Ethics ; Female ; Fibroblasts ; Fibrosis ; Gene deletion ; Genes ; Genetic diversity ; Genetic testing ; Genetic variance ; Genomes ; Genotyping ; Genotyping Techniques ; Glaucoma ; Graft Survival - genetics ; Haplotypes - genetics ; Hospitals ; Humans ; Immunology ; Inflammation ; Insertion ; Investigations ; Ireland ; Kaplan-Meier Estimate ; Kidney diseases ; Kidney Transplantation ; Kidney transplants ; Kidneys ; Linkage Disequilibrium - genetics ; Male ; Medical prognosis ; Medical research ; Medicine ; Membrane structures ; Nephrology ; Polymorphism, Single Nucleotide - genetics ; Proportional Hazards Models ; Proteins ; Renal failure ; Reproducibility of Results ; Sequence Analysis, DNA ; Signal transduction ; Single nucleotide polymorphisms ; Single-nucleotide polymorphism ; Studies ; Survival ; Transplantation ; Transplants ; Transplants & implants ; Treatment Outcome ; Type 2 diabetes</subject><ispartof>PloS one, 2013-05, Vol.8 (5), p.e63358-e63358</ispartof><rights>COPYRIGHT 2013 Public Library of Science</rights><rights>2013 McCaughan et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2013 McCaughan et al 2013 McCaughan et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-64f4f2520579f40edf43d565d579240d1b26cdcfe8f71058c2d652382b8e503e3</citedby><cites>FETCH-LOGICAL-c692t-64f4f2520579f40edf43d565d579240d1b26cdcfe8f71058c2d652382b8e503e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3646761/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3646761/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793,79600,79601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23667606$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Sen, Utpal</contributor><creatorcontrib>McCaughan, Jennifer A</creatorcontrib><creatorcontrib>Duffy, Seamus</creatorcontrib><creatorcontrib>O'Hagan, Thomas</creatorcontrib><creatorcontrib>Courtney, Aisling E</creatorcontrib><creatorcontrib>Borrows, Richard</creatorcontrib><creatorcontrib>Conlon, Peter J</creatorcontrib><creatorcontrib>Maxwell, Alexander P</creatorcontrib><creatorcontrib>McKnight, Amy Jayne</creatorcontrib><title>Comprehensive investigation of the caveolin 2 gene: resequencing and association for kidney transplant outcomes</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Caveolae are plasma membrane structures formed from a complex of the proteins caveolin-1 and caveolin-2. Caveolae interact with pro-inflammatory cytokines and are dysregulated in fibrotic disease. Although caveolae are present infrequently in healthy kidneys, they are abundant during kidney injury. An association has been identified between a CAV1 gene variant and long term kidney transplant survival. Chronic, gradual decline in transplant function is a persistent problem in kidney transplantation. The aetiology of this is diverse but fibrosis within the transplanted organ is the common end point. This study is the first to investigate the association of CAV2 gene variants with kidney transplant outcomes. Genomic DNA from donors and recipients of 575 kidney transplants performed in Belfast was investigated for common variation in CAV2 using a tag SNP approach. The CAV2 SNP rs13221869 was nominally significant for kidney transplant failure. Validation was sought in an independent group of kidney transplant donors and recipients from Dublin, Ireland using a second genotyping technology. Due to the unexpected absence of rs13221869 from this cohort, the CAV2 gene was resequenced. One novel SNP and a novel insertion/deletion in CAV2 were identified; rs13221869 is located in a repetitive region and was not a true variant in resequenced populations. CAV2 is a plausible candidate gene for association with kidney transplant outcomes given its proximity to CAV1 and its role in attenuating fibrosis. This study does not support an association between CAV2 variation and kidney transplant survival. Further analysis of CAV2 should be undertaken with an awareness of the sequence complexities and genetic variants highlighted by this study.</description><subject>Adult</subject><subject>Analysis</subject><subject>Biology</subject><subject>Caveolae</subject><subject>Caveolin</subject><subject>Caveolin 2 - genetics</subject><subject>Caveolin-1</subject><subject>Consent</subject><subject>Cytokines</subject><subject>Deoxyribonucleic acid</subject><subject>Diabetes</subject><subject>DNA</subject><subject>Donors</subject><subject>Ethics</subject><subject>Female</subject><subject>Fibroblasts</subject><subject>Fibrosis</subject><subject>Gene deletion</subject><subject>Genes</subject><subject>Genetic diversity</subject><subject>Genetic testing</subject><subject>Genetic variance</subject><subject>Genomes</subject><subject>Genotyping</subject><subject>Genotyping Techniques</subject><subject>Glaucoma</subject><subject>Graft Survival - genetics</subject><subject>Haplotypes - genetics</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Immunology</subject><subject>Inflammation</subject><subject>Insertion</subject><subject>Investigations</subject><subject>Ireland</subject><subject>Kaplan-Meier Estimate</subject><subject>Kidney diseases</subject><subject>Kidney Transplantation</subject><subject>Kidney transplants</subject><subject>Kidneys</subject><subject>Linkage Disequilibrium - genetics</subject><subject>Male</subject><subject>Medical prognosis</subject><subject>Medical research</subject><subject>Medicine</subject><subject>Membrane structures</subject><subject>Nephrology</subject><subject>Polymorphism, Single Nucleotide - genetics</subject><subject>Proportional Hazards Models</subject><subject>Proteins</subject><subject>Renal failure</subject><subject>Reproducibility of Results</subject><subject>Sequence Analysis, DNA</subject><subject>Signal transduction</subject><subject>Single nucleotide polymorphisms</subject><subject>Single-nucleotide polymorphism</subject><subject>Studies</subject><subject>Survival</subject><subject>Transplantation</subject><subject>Transplants</subject><subject>Transplants & implants</subject><subject>Treatment Outcome</subject><subject>Type 2 diabetes</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNk11v0zAUhiMEYmPwDxBYQkJw0eL4KwkXSFPFR6VJk_i6tVz7OPVI7c5OKvbvcWk2NWgXyBeJned9nfPapyiel3he0qp8dxWG6FU33wYPc4wFpbx-UJyWDSUzQTB9ePR-UjxJ6QpjTmshHhcnhApRCSxOi7AIm22ENfjkdoCc30HqXat6FzwKFvVrQFrtIHTOI4Ja8PAeRUhwPYDXzrdIeYNUSkG7g8iGiH454-EG9VH5tO2U71EYeh02kJ4Wj6zqEjwbn2fFj08fvy--zC4uPy8X5xczLRrSzwSzzBJOMK8ayzAYy6jhgps8JwybckWENtpCbasS81oTIzihNVnVwDEFela8PPhuu5DkmFWSJeW4EXV2ysTyQJigruQ2uo2KNzIoJ_8uhNhKFXunO5DACBGl0Yo3mJFqVVcsh81wDYAb0Dp7fRh3G1YbMBp8Lr2bmE6_eLeWbdhJKlg-iDIbvBkNYsjJpl5uXNLQ5ewgDIf_rhuOMcvoq3_Q-6sbqVblApy3Ie-r96bynFU1bfIQmZrfQ-VhYON0vljW5fWJ4O1EkJkefvetGlKSy29f_5-9_DllXx-xa1Bdv06hG_Y3Kk1BdgB1DClFsHchl1ju--I2DbnvCzn2RZa9OD6gO9FtI9A_gI4I0w</recordid><startdate>20130507</startdate><enddate>20130507</enddate><creator>McCaughan, Jennifer A</creator><creator>Duffy, Seamus</creator><creator>O'Hagan, Thomas</creator><creator>Courtney, Aisling E</creator><creator>Borrows, Richard</creator><creator>Conlon, Peter J</creator><creator>Maxwell, Alexander P</creator><creator>McKnight, Amy Jayne</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20130507</creationdate><title>Comprehensive investigation of the caveolin 2 gene: resequencing and association for kidney transplant outcomes</title><author>McCaughan, Jennifer A ; Duffy, Seamus ; O'Hagan, Thomas ; Courtney, Aisling E ; Borrows, Richard ; Conlon, Peter J ; Maxwell, Alexander P ; McKnight, Amy Jayne</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-64f4f2520579f40edf43d565d579240d1b26cdcfe8f71058c2d652382b8e503e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Analysis</topic><topic>Biology</topic><topic>Caveolae</topic><topic>Caveolin</topic><topic>Caveolin 2 - genetics</topic><topic>Caveolin-1</topic><topic>Consent</topic><topic>Cytokines</topic><topic>Deoxyribonucleic acid</topic><topic>Diabetes</topic><topic>DNA</topic><topic>Donors</topic><topic>Ethics</topic><topic>Female</topic><topic>Fibroblasts</topic><topic>Fibrosis</topic><topic>Gene deletion</topic><topic>Genes</topic><topic>Genetic diversity</topic><topic>Genetic testing</topic><topic>Genetic variance</topic><topic>Genomes</topic><topic>Genotyping</topic><topic>Genotyping Techniques</topic><topic>Glaucoma</topic><topic>Graft Survival - genetics</topic><topic>Haplotypes - genetics</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Immunology</topic><topic>Inflammation</topic><topic>Insertion</topic><topic>Investigations</topic><topic>Ireland</topic><topic>Kaplan-Meier Estimate</topic><topic>Kidney diseases</topic><topic>Kidney Transplantation</topic><topic>Kidney transplants</topic><topic>Kidneys</topic><topic>Linkage Disequilibrium - genetics</topic><topic>Male</topic><topic>Medical prognosis</topic><topic>Medical research</topic><topic>Medicine</topic><topic>Membrane structures</topic><topic>Nephrology</topic><topic>Polymorphism, Single Nucleotide - genetics</topic><topic>Proportional Hazards Models</topic><topic>Proteins</topic><topic>Renal failure</topic><topic>Reproducibility of Results</topic><topic>Sequence Analysis, DNA</topic><topic>Signal transduction</topic><topic>Single nucleotide polymorphisms</topic><topic>Single-nucleotide polymorphism</topic><topic>Studies</topic><topic>Survival</topic><topic>Transplantation</topic><topic>Transplants</topic><topic>Transplants & implants</topic><topic>Treatment Outcome</topic><topic>Type 2 diabetes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>McCaughan, Jennifer A</creatorcontrib><creatorcontrib>Duffy, Seamus</creatorcontrib><creatorcontrib>O'Hagan, Thomas</creatorcontrib><creatorcontrib>Courtney, Aisling E</creatorcontrib><creatorcontrib>Borrows, Richard</creatorcontrib><creatorcontrib>Conlon, Peter J</creatorcontrib><creatorcontrib>Maxwell, Alexander P</creatorcontrib><creatorcontrib>McKnight, Amy Jayne</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Opposing Viewpoints in Context (Gale)</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Proquest Nursing & Allied Health Source</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>McCaughan, Jennifer A</au><au>Duffy, Seamus</au><au>O'Hagan, Thomas</au><au>Courtney, Aisling E</au><au>Borrows, Richard</au><au>Conlon, Peter J</au><au>Maxwell, Alexander P</au><au>McKnight, Amy Jayne</au><au>Sen, Utpal</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comprehensive investigation of the caveolin 2 gene: resequencing and association for kidney transplant outcomes</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2013-05-07</date><risdate>2013</risdate><volume>8</volume><issue>5</issue><spage>e63358</spage><epage>e63358</epage><pages>e63358-e63358</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Caveolae are plasma membrane structures formed from a complex of the proteins caveolin-1 and caveolin-2. Caveolae interact with pro-inflammatory cytokines and are dysregulated in fibrotic disease. Although caveolae are present infrequently in healthy kidneys, they are abundant during kidney injury. An association has been identified between a CAV1 gene variant and long term kidney transplant survival. Chronic, gradual decline in transplant function is a persistent problem in kidney transplantation. The aetiology of this is diverse but fibrosis within the transplanted organ is the common end point. This study is the first to investigate the association of CAV2 gene variants with kidney transplant outcomes. Genomic DNA from donors and recipients of 575 kidney transplants performed in Belfast was investigated for common variation in CAV2 using a tag SNP approach. The CAV2 SNP rs13221869 was nominally significant for kidney transplant failure. Validation was sought in an independent group of kidney transplant donors and recipients from Dublin, Ireland using a second genotyping technology. Due to the unexpected absence of rs13221869 from this cohort, the CAV2 gene was resequenced. One novel SNP and a novel insertion/deletion in CAV2 were identified; rs13221869 is located in a repetitive region and was not a true variant in resequenced populations. CAV2 is a plausible candidate gene for association with kidney transplant outcomes given its proximity to CAV1 and its role in attenuating fibrosis. This study does not support an association between CAV2 variation and kidney transplant survival. Further analysis of CAV2 should be undertaken with an awareness of the sequence complexities and genetic variants highlighted by this study.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>23667606</pmid><doi>10.1371/journal.pone.0063358</doi><tpages>e63358</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Public Library of Science (PLoS); PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Adult Analysis Biology Caveolae Caveolin Caveolin 2 - genetics Caveolin-1 Consent Cytokines Deoxyribonucleic acid Diabetes DNA Donors Ethics Female Fibroblasts Fibrosis Gene deletion Genes Genetic diversity Genetic testing Genetic variance Genomes Genotyping Genotyping Techniques Glaucoma Graft Survival - genetics Haplotypes - genetics Hospitals Humans Immunology Inflammation Insertion Investigations Ireland Kaplan-Meier Estimate Kidney diseases Kidney Transplantation Kidney transplants Kidneys Linkage Disequilibrium - genetics Male Medical prognosis Medical research Medicine Membrane structures Nephrology Polymorphism, Single Nucleotide - genetics Proportional Hazards Models Proteins Renal failure Reproducibility of Results Sequence Analysis, DNA Signal transduction Single nucleotide polymorphisms Single-nucleotide polymorphism Studies Survival Transplantation Transplants Transplants & implants Treatment Outcome Type 2 diabetes |
| title | Comprehensive investigation of the caveolin 2 gene: resequencing and association for kidney transplant outcomes |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-06T22%3A11%3A48IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Comprehensive%20investigation%20of%20the%20caveolin%202%20gene:%20resequencing%20and%20association%20for%20kidney%20transplant%20outcomes&rft.jtitle=PloS%20one&rft.au=McCaughan,%20Jennifer%20A&rft.date=2013-05-07&rft.volume=8&rft.issue=5&rft.spage=e63358&rft.epage=e63358&rft.pages=e63358-e63358&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0063358&rft_dat=%3Cgale_plos_%3EA478393936%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1350968565&rft_id=info:pmid/23667606&rft_galeid=A478393936&rft_doaj_id=oai_doaj_org_article_e42261dca590427b874358408ee09ecc&rfr_iscdi=true |