KCNQ channels show conserved ethanol block and function in ethanol behaviour

In humans, KCNQ2/3 channels form an M-current that regulates neuronal excitability, with mutations in these channels causing benign neonatal familial convulsions. The M-current is important in mechanisms of neural plasticity underlying associative memory and in the response to ethanol, with KCNQ con...

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Veröffentlicht in:	PloS one 2012-11, Vol.7 (11), p.e50279
Hauptverfasser:	Cavaliere, Sonia, Gillespie, John M, Hodge, James J L
Format:	Artikel
Sprache:	eng
Schlagworte:	Alcohol Alcohols Animals Associative memory Biology Calcium Calcium - metabolism Calcium signalling Channels Cocaine Convulsions Crosses, Genetic Depolarization DNA, Complementary - metabolism Dopamine Dopamine receptors Drosophila Drosophila melanogaster Drug tolerance Electrophysiology - methods Ethanol Ethanol - pharmacology Excitability Gene Deletion Genes HEK293 Cells Humans Hypersensitivity Inhibitory Concentration 50 Insects KCNQ Potassium Channels - genetics KCNQ Potassium Channels - metabolism KCNQ2 protein Kinases Mammals Medicine Membrane potential Memory Mutation Neonates Nervous system Neurons Neurons - metabolism Neurophysiology Patch-Clamp Techniques Plasticity (neural) Potassium channels (voltage-gated) Proteins RNA Interference RNA-mediated interference Sensitivity Transient receptor potential proteins
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