A mucosal subunit vaccine protects against lethal respiratory infection with Francisella tularensis LVS

Francisella tularensis (FT) is a highly virulent pathogen for humans and other mammals. Severe morbidity and mortality is associated with respiratory FT infection and there are concerns about intentional dissemination of this organism. Therefore, FT has been designated a category A biothreat agent a...

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Veröffentlicht in:	PloS one 2012-11, Vol.7 (11), p.e50460-e50460
Hauptverfasser:	Ashtekar, Amit R, Katz, Jannet, Xu, Qingan, Michalek, Suzanne M
Format:	Artikel
Sprache:	eng
Schlagworte:	Alveoli Animals Antibodies Antigens Antigens, Bacterial - immunology Bacteria Bacterial Vaccines - therapeutic use Biology Bronchus CD4 antigen Cells, Cultured Dentistry DnaK protein Female Francisella tularensis Francisella tularensis - pathogenicity Health aspects Heat shock Heat shock proteins House mouse Immunization Immunoglobulin A Immunoglobulin G Immunoglobulins Infection Infections Interferon Interferon-gamma - metabolism Interleukin 10 Interleukin-10 - metabolism Interleukin-17 - metabolism Laboratory animals Liver Lung diseases Lungs Lymphocytes Lymphocytes T Medical research Medicine Mice Morbidity Mucosa Pediatrics Respiration Respiratory tract infection Respiratory Tract Infections - immunology Respiratory Tract Infections - metabolism Respiratory Tract Infections - prevention & control Rodents Spleen Studies T cells Tularemia Tularemia - immunology Tularemia - metabolism Tularemia - prevention & control Vaccines Vagina Virulence (Microbiology) γ-Interferon
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