Structures of coxsackievirus, rhinovirus, and poliovirus polymerase elongation complexes solved by engineering RNA mediated crystal contacts

RNA-dependent RNA polymerases play a vital role in the growth of RNA viruses where they are responsible for genome replication, but do so with rather low fidelity that allows for the rapid adaptation to different host cell environments. These polymerases are also a target for antiviral drug developm...

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Veröffentlicht in:	PloS one 2013-05, Vol.8 (5), p.e60272
Hauptverfasser:	Gong, Peng, Kortus, Matthew G, Nix, Jay C, Davis, Ralph E, Peersen, Olve B
Format:	Artikel
Sprache:	eng
Schlagworte:	Base pairs BASIC BIOLOGICAL SCIENCES Binding Sites - genetics Biochemistry Biology Catalysis Conformation Conservation Coxsackievirus infections Coxsackieviruses Crystal lattices crystal structure Crystallization DNA-directed RNA polymerase Drug development Drug discovery Elongated structure Elongation Engineering Enterovirus B, Human - enzymology Enzymes Fidelity Genetic Engineering - methods Genomes Genomics Intermediates Laboratories Magnesium Models, Molecular Molecular biology Mutation nucleotides Poliovirus Poliovirus - enzymology polymerases Protein Conformation Rhinovirus Rhinovirus - enzymology Ribonucleic acid RNA RNA - chemistry RNA - metabolism RNA polymerases RNA Replicase - chemistry RNA Replicase - metabolism RNA structure RNA viruses Structure-function relationships Translocation viral structure Virology Viruses
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