Crosstalk from non-cancerous mitochondria can inhibit tumor properties of metastatic cells by suppressing oncogenic pathways

Mitochondrial-nucleus cross talks and mitochondrial retrograde regulation can play a significant role in cellular properties. Transmitochondrial cybrid systems (cybrids) are an excellent tool to study specific effects of altered mitochondria under a defined nuclear background. The majority of the st...

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Veröffentlicht in:	PloS one 2013-05, Vol.8 (5), p.e61747
Hauptverfasser:	Kaipparettu, Benny Abraham, Ma, Yewei, Park, Jun Hyoung, Lee, Tin-Lap, Zhang, Yiqun, Yotnda, Patricia, Creighton, Chad J, Chan, Wai-Yee, Wong, Lee-Jun C
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - metabolism Agar Analysis Animals Antibiotics, Antineoplastic - pharmacology Anticancer properties Apoptosis B cells Benign Biocompatibility Biology Biomedical materials Bone cancer Breast cancer Cancer Cancer metastasis Cancer therapies Cancer treatment Cell Hypoxia Cell Line Cell Line, Tumor Cell Nucleus - genetics Cell Nucleus - metabolism Cell proliferation Cell Survival - drug effects Cell Survival - genetics Cell Transformation, Neoplastic - genetics Cell Transformation, Neoplastic - metabolism Cell Transformation, Neoplastic - pathology Chemotherapy Childrens health Crosstalk Cybrids Defects Deoxyribonucleic acid DNA DNA methylation DNA microarrays DNA, Mitochondrial - genetics DNA, Mitochondrial - metabolism Doxorubicin - pharmacology Electron transport Epigenetics Epithelial cells Female Gene expression Genetic aspects Genetics Genomes Genomics Heterografts Humans Hybrid Cells - drug effects Hybrid Cells - metabolism Hypoxia Mammary Neoplasms, Experimental - genetics Mammary Neoplasms, Experimental - metabolism Mammary Neoplasms, Experimental - pathology Medicine Metastases Metastasis Mice Mice, Nude Mitochondria Mitochondria - genetics Mitochondria - metabolism Mitochondrial DNA Mutation Neoplasm Metastasis Nuclei Nuclei (cytology) Oligonucleotide Array Sequence Analysis Osteosarcoma Oxygen Oxygen consumption Pathways Reactive Oxygen Species - metabolism Reverse Transcriptase Polymerase Chain Reaction Reversing Sarcoma Signal Transduction - genetics Studies Transcriptome - drug effects Transcriptome - genetics Tumors Viability Vitamin E
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