The coexistence of asthma and chronic obstructive pulmonary disease (COPD): prevalence and risk factors in young, middle-aged and elderly people from the general population
The joint distribution of asthma and chronic obstructive pulmonary disease (COPD) has not been well described. This study aims at determining the prevalence of self-reported physician diagnoses of asthma, COPD and of the asthma-COPD overlap syndrome and to assess whether these conditions share a com...
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| Veröffentlicht in: | PloS one 2013-05, Vol.8 (5), p.e62985-e62985 |
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| creator | de Marco, Roberto Pesce, Giancarlo Marcon, Alessandro Accordini, Simone Antonicelli, Leonardo Bugiani, Massimiliano Casali, Lucio Ferrari, Marcello Nicolini, Gabriele Panico, Maria Grazia Pirina, Pietro Zanolin, Maria Elisabetta Cerveri, Isa Verlato, Giuseppe |
| description | The joint distribution of asthma and chronic obstructive pulmonary disease (COPD) has not been well described. This study aims at determining the prevalence of self-reported physician diagnoses of asthma, COPD and of the asthma-COPD overlap syndrome and to assess whether these conditions share a common set of risk factors.
A screening questionnaire on respiratory symptoms, diagnoses and risk factors was administered by mail or phone to random samples of the general Italian population aged 20-44 (n = 5163) 45-64 (n = 2167) and 65-84 (n = 1030) in the frame of the multicentre Gene Environment Interactions in Respiratory Diseases (GEIRD) study.
A physician diagnosis of asthma or COPD (emphysema/chronic bronchitis/COPD) was reported by 13% and 21% of subjects aged |
| doi_str_mv | 10.1371/journal.pone.0062985 |
| format | Article |
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A screening questionnaire on respiratory symptoms, diagnoses and risk factors was administered by mail or phone to random samples of the general Italian population aged 20-44 (n = 5163) 45-64 (n = 2167) and 65-84 (n = 1030) in the frame of the multicentre Gene Environment Interactions in Respiratory Diseases (GEIRD) study.
A physician diagnosis of asthma or COPD (emphysema/chronic bronchitis/COPD) was reported by 13% and 21% of subjects aged <65 and 65-84 years respectively. Aging was associated with a marked decrease in the prevalence of diagnosed asthma (from 8.2% to 1.6%) and with a marked increase in the prevalence of diagnosed COPD (from 3.3% to 13.3%). The prevalence of the overlap of asthma and COPD was 1.6% (1.3%-2.0%), 2.1% (1.5%-2.8%) and 4.5% (3.2%-5.9%) in the 20-44, 45-64 and 65-84 age groups. Subjects with both asthma and COPD diagnoses were more likely to have respiratory symptoms, physical impairment, and to report hospital admissions compared to asthma or COPD alone (p<0.01). Age, sex, education and smoking showed different and sometimes opposite associations with the three conditions.
Asthma and COPD are common in the general population, and they coexist in a substantial proportion of subjects. The asthma-COPD overlap syndrome represents an important clinical phenotype that deserves more medical attention and further research.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0062985</identifier><identifier>PMID: 23675448</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Age Factors ; Aged ; Aged, 80 and over ; Aging ; Allergies ; Asthma ; Asthma - complications ; Asthma - epidemiology ; Biology ; Bronchitis ; Chronic obstructive pulmonary disease ; Coexistence ; Comorbidity ; Dyspnea ; Emphysema ; Epidemiology ; Female ; Geriatrics ; Health risks ; Hospitalization ; Humans ; Internal medicine ; Italy - epidemiology ; Lung diseases ; Male ; Medical research ; Medical statistics ; Medicine ; Middle age ; Middle Aged ; Obstructive lung disease ; Older people ; Population ; Population Surveillance ; Prevalence ; Primary care ; Pulmonary Disease, Chronic Obstructive - complications ; Pulmonary Disease, Chronic Obstructive - epidemiology ; Questionnaires ; Respiratory diseases ; Risk analysis ; Risk Factors ; Self Report ; Smoking ; Studies ; Systematic review ; Young Adult ; Young adults</subject><ispartof>PloS one, 2013-05, Vol.8 (5), p.e62985-e62985</ispartof><rights>COPYRIGHT 2013 Public Library of Science</rights><rights>2013 de Marco et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2013 de Marco et al 2013 de Marco et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c659t-e7cecd93e37f8110898086d676e335c35982132e199849882e1769042d39e0af3</citedby><cites>FETCH-LOGICAL-c659t-e7cecd93e37f8110898086d676e335c35982132e199849882e1769042d39e0af3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3651288/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3651288/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23847,27903,27904,53769,53771,79346,79347</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23675448$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Bayer, Antony</contributor><creatorcontrib>de Marco, Roberto</creatorcontrib><creatorcontrib>Pesce, Giancarlo</creatorcontrib><creatorcontrib>Marcon, Alessandro</creatorcontrib><creatorcontrib>Accordini, Simone</creatorcontrib><creatorcontrib>Antonicelli, Leonardo</creatorcontrib><creatorcontrib>Bugiani, Massimiliano</creatorcontrib><creatorcontrib>Casali, Lucio</creatorcontrib><creatorcontrib>Ferrari, Marcello</creatorcontrib><creatorcontrib>Nicolini, Gabriele</creatorcontrib><creatorcontrib>Panico, Maria Grazia</creatorcontrib><creatorcontrib>Pirina, Pietro</creatorcontrib><creatorcontrib>Zanolin, Maria Elisabetta</creatorcontrib><creatorcontrib>Cerveri, Isa</creatorcontrib><creatorcontrib>Verlato, Giuseppe</creatorcontrib><title>The coexistence of asthma and chronic obstructive pulmonary disease (COPD): prevalence and risk factors in young, middle-aged and elderly people from the general population</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>The joint distribution of asthma and chronic obstructive pulmonary disease (COPD) has not been well described. This study aims at determining the prevalence of self-reported physician diagnoses of asthma, COPD and of the asthma-COPD overlap syndrome and to assess whether these conditions share a common set of risk factors.
A screening questionnaire on respiratory symptoms, diagnoses and risk factors was administered by mail or phone to random samples of the general Italian population aged 20-44 (n = 5163) 45-64 (n = 2167) and 65-84 (n = 1030) in the frame of the multicentre Gene Environment Interactions in Respiratory Diseases (GEIRD) study.
A physician diagnosis of asthma or COPD (emphysema/chronic bronchitis/COPD) was reported by 13% and 21% of subjects aged <65 and 65-84 years respectively. Aging was associated with a marked decrease in the prevalence of diagnosed asthma (from 8.2% to 1.6%) and with a marked increase in the prevalence of diagnosed COPD (from 3.3% to 13.3%). The prevalence of the overlap of asthma and COPD was 1.6% (1.3%-2.0%), 2.1% (1.5%-2.8%) and 4.5% (3.2%-5.9%) in the 20-44, 45-64 and 65-84 age groups. Subjects with both asthma and COPD diagnoses were more likely to have respiratory symptoms, physical impairment, and to report hospital admissions compared to asthma or COPD alone (p<0.01). Age, sex, education and smoking showed different and sometimes opposite associations with the three conditions.
Asthma and COPD are common in the general population, and they coexist in a substantial proportion of subjects. The asthma-COPD overlap syndrome represents an important clinical phenotype that deserves more medical attention and further research.</description><subject>Adult</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Aging</subject><subject>Allergies</subject><subject>Asthma</subject><subject>Asthma - complications</subject><subject>Asthma - epidemiology</subject><subject>Biology</subject><subject>Bronchitis</subject><subject>Chronic obstructive pulmonary disease</subject><subject>Coexistence</subject><subject>Comorbidity</subject><subject>Dyspnea</subject><subject>Emphysema</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Geriatrics</subject><subject>Health risks</subject><subject>Hospitalization</subject><subject>Humans</subject><subject>Internal medicine</subject><subject>Italy - epidemiology</subject><subject>Lung diseases</subject><subject>Male</subject><subject>Medical research</subject><subject>Medical statistics</subject><subject>Medicine</subject><subject>Middle age</subject><subject>Middle Aged</subject><subject>Obstructive lung disease</subject><subject>Older people</subject><subject>Population</subject><subject>Population Surveillance</subject><subject>Prevalence</subject><subject>Primary care</subject><subject>Pulmonary Disease, Chronic Obstructive - complications</subject><subject>Pulmonary Disease, Chronic Obstructive - epidemiology</subject><subject>Questionnaires</subject><subject>Respiratory diseases</subject><subject>Risk analysis</subject><subject>Risk Factors</subject><subject>Self Report</subject><subject>Smoking</subject><subject>Studies</subject><subject>Systematic review</subject><subject>Young Adult</subject><subject>Young 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Pietro</au><au>Zanolin, Maria Elisabetta</au><au>Cerveri, Isa</au><au>Verlato, Giuseppe</au><au>Bayer, Antony</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The coexistence of asthma and chronic obstructive pulmonary disease (COPD): prevalence and risk factors in young, middle-aged and elderly people from the general population</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2013-05-10</date><risdate>2013</risdate><volume>8</volume><issue>5</issue><spage>e62985</spage><epage>e62985</epage><pages>e62985-e62985</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>The joint distribution of asthma and chronic obstructive pulmonary disease (COPD) has not been well described. This study aims at determining the prevalence of self-reported physician diagnoses of asthma, COPD and of the asthma-COPD overlap syndrome and to assess whether these conditions share a common set of risk factors.
A screening questionnaire on respiratory symptoms, diagnoses and risk factors was administered by mail or phone to random samples of the general Italian population aged 20-44 (n = 5163) 45-64 (n = 2167) and 65-84 (n = 1030) in the frame of the multicentre Gene Environment Interactions in Respiratory Diseases (GEIRD) study.
A physician diagnosis of asthma or COPD (emphysema/chronic bronchitis/COPD) was reported by 13% and 21% of subjects aged <65 and 65-84 years respectively. Aging was associated with a marked decrease in the prevalence of diagnosed asthma (from 8.2% to 1.6%) and with a marked increase in the prevalence of diagnosed COPD (from 3.3% to 13.3%). The prevalence of the overlap of asthma and COPD was 1.6% (1.3%-2.0%), 2.1% (1.5%-2.8%) and 4.5% (3.2%-5.9%) in the 20-44, 45-64 and 65-84 age groups. Subjects with both asthma and COPD diagnoses were more likely to have respiratory symptoms, physical impairment, and to report hospital admissions compared to asthma or COPD alone (p<0.01). Age, sex, education and smoking showed different and sometimes opposite associations with the three conditions.
Asthma and COPD are common in the general population, and they coexist in a substantial proportion of subjects. The asthma-COPD overlap syndrome represents an important clinical phenotype that deserves more medical attention and further research.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>23675448</pmid><doi>10.1371/journal.pone.0062985</doi><oa>free_for_read</oa></addata></record> |
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| recordid | cdi_plos_journals_1350368619 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry; Public Library of Science (PLoS) |
| subjects | Adult Age Factors Aged Aged, 80 and over Aging Allergies Asthma Asthma - complications Asthma - epidemiology Biology Bronchitis Chronic obstructive pulmonary disease Coexistence Comorbidity Dyspnea Emphysema Epidemiology Female Geriatrics Health risks Hospitalization Humans Internal medicine Italy - epidemiology Lung diseases Male Medical research Medical statistics Medicine Middle age Middle Aged Obstructive lung disease Older people Population Population Surveillance Prevalence Primary care Pulmonary Disease, Chronic Obstructive - complications Pulmonary Disease, Chronic Obstructive - epidemiology Questionnaires Respiratory diseases Risk analysis Risk Factors Self Report Smoking Studies Systematic review Young Adult Young adults |
| title | The coexistence of asthma and chronic obstructive pulmonary disease (COPD): prevalence and risk factors in young, middle-aged and elderly people from the general population |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-27T15%3A29%3A39IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20coexistence%20of%20asthma%20and%20chronic%20obstructive%20pulmonary%20disease%20(COPD):%20prevalence%20and%20risk%20factors%20in%20young,%20middle-aged%20and%20elderly%20people%20from%20the%20general%20population&rft.jtitle=PloS%20one&rft.au=de%20Marco,%20Roberto&rft.date=2013-05-10&rft.volume=8&rft.issue=5&rft.spage=e62985&rft.epage=e62985&rft.pages=e62985-e62985&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0062985&rft_dat=%3Cgale_plos_%3EA478343470%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1350368619&rft_id=info:pmid/23675448&rft_galeid=A478343470&rft_doaj_id=oai_doaj_org_article_a56237d796794dea9171aeec66fe713d&rfr_iscdi=true |