First insight into the kinome of human regulatory T cells

Regulatory T cells (Tregs) are essential for controlling peripheral tolerance by the active suppression of various immune cells including conventional T effector cells (Teffs). Downstream of the T cell receptor (TCR), more than 500 protein kinases encoded by the human genome have to be considered in...

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Veröffentlicht in:	PloS one 2012-07, Vol.7 (7), p.e40896-e40896
Hauptverfasser:	König, Sebastian, Probst-Kepper, Michael, Reinl, Tobias, Jeron, Andreas, Huehn, Jochen, Schraven, Burkhart, Jänsch, Lothar
Format:	Artikel
Sprache:	eng
Schlagworte:	Active control Amino Acid Sequence Biology Cascades CD4 antigen Cell cycle Cell growth Cell Proliferation Cyclin-Dependent Kinase 6 - chemistry Cyclin-Dependent Kinase 6 - metabolism Cyclin-dependent kinases Cytokines Effector cells Foxp3 protein Gene expression Genomes Genomics Genotype & phenotype Humans Immune system Immunological tolerance Immunology Immunoregulation Kinases Lymphocytes Lymphocytes T Mass spectrometry Molecular Sequence Data Peptides - chemistry Peptides - metabolism Phenotype Phosphorylation Protein kinase Protein kinases Protein Kinases - metabolism Proteins Proteome - metabolism Proteomics Scientific imaging Signal Transduction - immunology Signaling Studies T cell receptors T cells T-cell receptor T-Lymphocytes, Regulatory - cytology T-Lymphocytes, Regulatory - enzymology T-Lymphocytes, Regulatory - immunology Transcription factors
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