Methyl donor supplementation blocks the adverse effects of maternal high fat diet on offspring physiology

Maternal consumption of a high fat diet during pregnancy increases the offspring risk for obesity. Using a mouse model, we have previously shown that maternal consumption of a high fat (60%) diet leads to global and gene specific decreases in DNA methylation in the brain of the offspring. The presen...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PloS one 2013-05, Vol.8 (5), p.e63549
Hauptverfasser:	Carlin, Jesselea, George, Robert, Reyes, Teresa M
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Analysis Animals Behavior, Animal Biology Body mass index Body Weight - genetics Body weight gain Brain Carbohydrates Central nervous system Consumption Deoxyribonucleic acid Diet Diet, High-Fat - adverse effects Dietary supplements DNA DNA Methylation Dopamine Dopamine transporter Epigenetics Experiments Female Females Food Gender aspects Gene expression Genes High fat diet Male Males Maternal Exposure - adverse effects Medicine Methylation Mice Mothers Motor Activity - genetics Nutrition Obesity Offspring Opioid receptors (type mu) Pharmacology Phenotype Physiological aspects Prefrontal cortex Pregnancy Public health RNA Rodents Sex Characteristics Sex differences Side effects Sucrose Vitamin B Weight control Womens health
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!