Differential effects of phosphatase inhibitors on the calcium homeostasis and migration of HaCaT keratinocytes

Changes in intracellular calcium concentration ([Ca²⁺]i) as well as in the phosphorylation state of proteins have been implicated in keratinocyte wound healing revealed in scratch assays. Scratching confluent HaCaT monolayers decreased the number of cells displaying repetitive Ca²⁺ oscillations as w...

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Veröffentlicht in:	PloS one 2013-04, Vol.8 (4), p.e61507
Hauptverfasser:	Ruzsnavszky, Olga, Dienes, Beatrix, Oláh, Tamás, Vincze, János, Gáll, Tamás, Balogh, Enikő, Nagy, Gábor, Bátori, Róbert, Lontay, Beáta, Erdődi, Ferenc, Csernoch, Laszlo
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Biology Calcium Calcium (intracellular) Calcium content Calcium homeostasis Calcium Signaling Calcium signalling Calcium transport Cell adhesion & migration Cell Line Cell migration Cell Movement - drug effects Cells, Cultured Contractility Enzyme Inhibitors - pharmacology Healing Homeostasis Homeostasis - drug effects Humans Inhibitors Keratinocytes Keratinocytes - drug effects Keratinocytes - physiology Kinases Musculoskeletal system Okadaic acid Okadaic Acid - pharmacology Oscillations Oxazoles - pharmacology Phosphatase Phosphoprotein phosphatase Phosphoprotein Phosphatases - antagonists & inhibitors Phosphorylation Physiology Protein phosphatase Proteins Rodents Scratching Wavelet transforms Wound healing
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