Regulation of TAK1/TAB1-mediated IL-1β signaling by cytoplasmic PPARβ/δ

The peroxisome proliferator-activated receptor subtypes PPARα, PPARβ/δ, PPARγ are members of the steroid hormone receptor superfamily with well-established functions in transcriptional regulation. Here, we describe an unexpected cytoplasmic function of PPARβ/δ. Silencing of PPARβ/δ expression interf...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PloS one 2013-04, Vol.8 (4), p.e63011
Hauptverfasser:	Stockert, Josefine, Wolf, Alexander, Kaddatz, Kerstin, Schnitzer, Evelyn, Finkernagel, Florian, Meissner, Wolfgang, Müller-Brüsselbach, Sabine, Kracht, Michael, Müller, Rolf
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - metabolism Apoptosis Biology Cancer Cytokines Cytoplasm - metabolism Fatty acids Gene expression Gene Expression Profiling Gene Expression Regulation Gene regulation Genomes Growth factors Heat shock proteins HeLa Cells HSP27 Heat-Shock Proteins - metabolism Hsp27 protein Humans IL-1β Inflammation Interleukin-1beta - metabolism Interleukin-1beta - pharmacology Interleukins Kinases Ligands MAP Kinase Kinase Kinases - chemistry MAP Kinase Kinase Kinases - metabolism Metabolism Metabolites Molecular biology Musculoskeletal system NF-κB protein Phosphorylation PPAR delta - metabolism PPAR-beta - metabolism Protein Binding Protein Interaction Domains and Motifs RelA protein Rodents Signal Transduction Signaling Skin TAK1 protein Transcription Transcription Factor RelA - metabolism Transcription factors Transcription, Genetic - drug effects
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!