RNA profiles of porcine embryos during genome activation reveal complex metabolic switch sensitive to in vitro conditions

Fertilization is followed by complex changes in cytoplasmic composition and extensive chromatin reprogramming which results in the abundant activation of totipotent embryonic genome at embryonic genome activation (EGA). While chromatin reprogramming has been widely studied in several species, only a...

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Veröffentlicht in:	PloS one 2013-04, Vol.8 (4), p.e61547-e61547
Hauptverfasser:	Østrup, Olga, Olbricht, Gayla, Østrup, Esben, Hyttel, Poul, Collas, Philippe, Cabot, Ryan
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Animal sciences Animals Annotations Apoptosis Biology Catabolism Cell cycle Chromatin remodeling Culture Techniques Deoxyribonucleic acid DNA Embryo, Mammalian - embryology Embryo, Mammalian - metabolism Embryos Fertilization Fertilization - genetics Gene expression Gene Expression Profiling Genome - genetics Genomes Humans In vivo methods and tests Laboratories Medical research Metabolic pathways Metabolic rate Metabolism Mice Mitosis Polyvinyl alcohol Reproducibility of Results Ribonucleic acid RNA RNA - genetics RNA processing RNA Splicing Sequence Analysis, RNA Species Specificity Splicing Stem cells Swine Transcription factors Translation Veterinary medicine
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