Altered reward circuitry in the norepinephrine transporter knockout mouse

Synaptic levels of the monoamine neurotransmitters dopamine, serotonin, and norepinephrine are modulated by their respective plasma membrane transporters, albeit with a few exceptions. Monoamine transporters remove monoamines from the synaptic cleft and thus influence the degree and duration of sign...

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Veröffentlicht in:	PloS one 2013-03, Vol.8 (3), p.e57597-e57597
Hauptverfasser:	Gallagher, Joseph J, Zhang, Xiaowei, Hall, F Scott, Uhl, George R, Bearer, Elaine L, Jacobs, Russell E
Format:	Artikel
Sprache:	eng
Schlagworte:	Addictions Animals Antidepressants Anxiety Aspartic Acid - analogs & derivatives Aspartic Acid - metabolism Attention deficit hyperactivity disorder Biological transport Biology Brain Brain - metabolism Brain - pathology Brain - physiopathology Brain Mapping Brain research Catecholamines Circuits Cocaine Contrast Media - administration & dosage Correlation analysis Cortex Dopamine Dopamine Plasma Membrane Transport Proteins - deficiency Dopamine Plasma Membrane Transport Proteins - genetics Dopamine transporter Drug abuse Female Imaging techniques In vivo methods and tests Injections, Intraventricular Magnetic resonance Magnetic Resonance Imaging Male Manganese Manganese - administration & dosage Medical imaging Mental depression Mental disorders Metabolism Metabolites Mice Mice, Knockout Monoamine transporter Monoamines Morphometry Neostriatum Neural circuitry Neural networks Neurobiology Neuroimaging Neurological diseases Neurons - physiology Neurosciences Neurotransmitters Norepinephrine Norepinephrine Plasma Membrane Transport Proteins - deficiency Norepinephrine Plasma Membrane Transport Proteins - genetics Norepinephrine transporter Observations Psychological aspects Reinforcement Reward Rodents Serotonin Serotonin Plasma Membrane Transport Proteins - deficiency Serotonin Plasma Membrane Transport Proteins - genetics Serotonin transporter Signaling Spectrum analysis Stereotaxic Techniques Synaptic cleft Synaptic Transmission - physiology Transmitters
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