Mitochondrial peroxiredoxin 3 regulates sensory cell survival in the cochlea

This study delineates the role of peroxiredoxin 3 (Prx3) in hair cell death induced by several etiologies of acquired hearing loss (noise trauma, aminoglycoside treatment, age). In vivo, Prx3 transiently increased in mouse cochlear hair cells after traumatic noise exposure, kanamycin treatment, or w...

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Veröffentlicht in:	PloS one 2013-04, Vol.8 (4), p.e61999
Hauptverfasser:	Chen, Fu-Quan, Zheng, Hong-Wei, Schacht, Jochen, Sha, Su-Hua
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Aging Aminoglycoside antibiotics Animals Antibacterial agents Antioxidants Apoptosis Auditory defects Biology Cell Death Cell survival Cell Survival - genetics Cochlea Etiology Explants Free Radical Scavengers - pharmacology Gene expression Gene Expression Regulation Gentamicin Gentamicins Hair Hair cells Hair Cells, Auditory - metabolism Hair Cells, Auditory - pathology Hearing loss Hearing Loss, Sensorineural - chemically induced Hearing Loss, Sensorineural - genetics Hearing Loss, Sensorineural - metabolism Hearing Loss, Sensorineural - pathology Homeodomain Proteins - antagonists & inhibitors Homeodomain Proteins - genetics Homeodomain Proteins - metabolism Homeostasis Hydroxybenzoates - pharmacology Kanamycin Kinases Laboratory animals Male Medicine Mice Mice, Inbred CBA Mitochondria Mortality mRNA Noise Noise control Noise levels Organ of Corti Otolaryngology Oxidative Stress Oxygen Pathology Peroxiredoxin Phenylenediamine Proteins Reactive oxygen species RNA RNA, Small Interfering - genetics RNA, Small Interfering - metabolism Rodents Severity of Illness Index siRNA Trauma
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