Divergent roles of amino acid residues inside and outside the BB loop affect human Toll-like receptor (TLR)2/2, TLR2/1 and TLR2/6 responsiveness

TLR2 specifically recognizes a wide range of ligands by homodimerizing or heterodimerizing with TLR1 or TLR6. However, the molecular basis of the specific signalling transduction induced by TLR2 homodimerization or heterodimerization with TLR1 or TLR6 is largely unknown. In this study, we found thre...

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Veröffentlicht in:	PloS one 2013-04, Vol.8 (4), p.e61508
Hauptverfasser:	Qiu, Yuan, Ding, Yan, Zou, Lingyun, Tan, Zhangping, Liu, Taiping, Fu, Xiaolan, Xu, Wenyue
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Amino Acid Sequence Amino Acid Substitution Amino acids Amino Acids - chemistry Amino Acids - genetics Amino Acids - metabolism Bacteria Binding Sites Biology Cellular signal transduction Cloning Conserved Sequence Gene Expression Regulation GLP-1 receptor agonists HEK293 Cells Human behavior Humans Immune system Interleukin 1 receptors Ligands Models, Molecular Molecular Sequence Data Mutagenesis Mutants Mutation MyD88 protein Myeloid Differentiation Factor 88 - chemistry Myeloid Differentiation Factor 88 - genetics Myeloid Differentiation Factor 88 - metabolism Protein Binding Protein Interaction Domains and Motifs Protein Multimerization Proteins Residues Sequence Alignment Signal transduction Signal Transduction - genetics Signaling Static Electricity Surface charge TLR1 protein TLR2 protein TLR3 protein Toll-Like Receptor 1 - chemistry Toll-Like Receptor 1 - genetics Toll-Like Receptor 1 - metabolism Toll-Like Receptor 2 - chemistry Toll-Like Receptor 2 - genetics Toll-Like Receptor 2 - metabolism Toll-Like Receptor 6 - chemistry Toll-Like Receptor 6 - genetics Toll-Like Receptor 6 - metabolism Toll-like receptors Transfection
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