Insulin regulates hypoxia-inducible factor-1α transcription by reactive oxygen species sensitive activation of Sp1 in 3T3-L1 preadipocyte

Oxygen sensing transcription factor HIF-1 is activated due to accumulation of regulatory subunit HIF-1α by posttranslational stability mechanism during hypoxia or by several other stimuli even in normoxia. HIF-1α is also regulated by NF-kB mediated transcription mechanism. Reactive oxygen species (R...

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Veröffentlicht in:	PloS one 2013-04, Vol.8 (4), p.e62128
Hauptverfasser:	Biswas, Sudipta, Mukherjee, Reshmi, Tapryal, Nisha, Singh, Amit K, Mukhopadhyay, Chinmay K
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase 3T3-L1 Cells 5' Flanking Region Activation Adipocytes Adipocytes - drug effects Adipocytes - metabolism Angiogenesis Animals Biology Chromatin Cobalt Dihydrofolate reductase Electrophoretic mobility Gene expression Gene Expression Regulation Homeostasis Hypoxia Hypoxia-inducible factor 1 Hypoxia-Inducible Factor 1, alpha Subunit - genetics Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Hypoxia-inducible factors Immunoprecipitation Insulin Insulin - pharmacology Kinases Medicine Mice Mitochondrial DNA Mutation NF-κB protein Oxygen Phosphatidylinositol 3-Kinases - metabolism Phosphorylation Prolyl hydroxylase Protein kinase C Protein Kinase C - metabolism Protein Stability - drug effects Proteins Pulmonary arteries Reactive oxygen species Reactive Oxygen Species - metabolism Response Elements RNA, Messenger - genetics Sequence Deletion Signal transduction Signaling Smooth muscle Sp1 protein Sp1 Transcription Factor - metabolism Stability analysis Transcription factors Transcription, Genetic - drug effects Vascular endothelial growth factor
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