Synergistic effect of CTLA-4 blockade and cancer chemotherapy in the induction of anti-tumor immunity

Several chemotherapeutics exert immunomodulatory effects. One of these is the nucleoside analogue gemcitabine, which is widely used in patients with lung cancer, ovarian cancer, breast cancer, mesothelioma and several other types of cancer, but with limited efficacy. We hypothesized that the immunop...

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Veröffentlicht in:	PloS one 2013-04, Vol.8 (4), p.e61895
Hauptverfasser:	Lesterhuis, W Joost, Salmons, Joanne, Nowak, Anna K, Rozali, Esdy N, Khong, Andrea, Dick, Ian M, Harken, Julie A, Robinson, Bruce W, Lake, Richard A
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animal models Animals Antibodies Antibodies, Monoclonal - pharmacology Antigens Antimitotic agents Antineoplastic agents Apoptosis Asbestos Biology Blocking antibodies Breast cancer Cancer Cancer therapies Carcinoma, Lewis Lung - drug therapy Carcinoma, Lewis Lung - immunology Carcinoma, Lewis Lung - mortality Carcinoma, Lewis Lung - pathology CD4 antigen CD4-Positive T-Lymphocytes - drug effects CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - pathology CD8 antigen CD8-Positive T-Lymphocytes - drug effects CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - pathology Chemotherapy Clinical trials CTLA-4 protein Cytotoxicity Deoxycytidine - analogs & derivatives Deoxycytidine - pharmacology Drug approval Drug dosages Drug Synergism Drug Therapy, Combination Drugs Ethics Gemcitabine Hospitals Immune checkpoint Immune response Immune system Immunity Immunity, Innate - drug effects Immunogenicity Immunologic Factors - pharmacology Immunology Immunomodulation Immunosuppressive agents Immunotherapy Lung cancer Lung diseases Lung Neoplasms - drug therapy Lung Neoplasms - immunology Lung Neoplasms - mortality Lung Neoplasms - pathology Lymphocyte Depletion Lymphocytes Lymphocytes T Medical research Medicine Melanoma Mesothelioma Mesothelioma - drug therapy Mesothelioma - immunology Mesothelioma - mortality Mesothelioma - pathology Metastases Metastasis Mice Mice, Transgenic Neoplasm Transplantation Nucleoside analogs Oncology Ovarian cancer Ovarian carcinoma Patients Pharmacology Survival Analysis Synergistic effect T cell receptors T cells Tumor Burden - drug effects Tumors Viral antibodies
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