ATM influences the efficiency of TCRβ rearrangement, subsequent TCRβ-dependent T cell development, and generation of the pre-selection TCRβ CDR3 repertoire

Generation and resolution of DNA double-strand breaks is required to assemble antigen-specific receptors from the genes encoding V, D, and J gene segments during recombination. The present report investigates the requirement for ataxia telangiectasia-mutated (ATM) kinase, a component of DNA double-s...

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Veröffentlicht in:	PloS one 2013-04, Vol.8 (4), p.e62188-e62188
Hauptverfasser:	Hathcock, Karen S, Bowen, Steven, Livak, Ferenc, Hodes, Richard J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens Ataxia Ataxia telangiectasia mutated protein Ataxia Telangiectasia Mutated Proteins - deficiency Ataxia Telangiectasia Mutated Proteins - genetics Ataxia Telangiectasia Mutated Proteins - metabolism Biology Cancer CD4 antigen CD8 antigen Cell cycle Cell Division - genetics Cell Line Cell Survival - genetics Complementarity Determining Regions - genetics Complementarity-determining region Complementarity-determining region 3 Defects Deoxyribonucleic acid Developmental stages DNA DNA Breaks, Double-Stranded DNA damage DNA repair DNA sequencing Double-strand break repair Gene Order Gene Rearrangement, beta-Chain T-Cell Antigen Receptor Gene sequencing Genes Immunoglobulins Immunology J gene Lymphocytes Lymphocytes T Mice Mice, Knockout Receptors Receptors, Antigen, T-Cell, alpha-beta - genetics Recombination T cell receptors T-Lymphocytes - metabolism Thymocytes Thymocytes - metabolism
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