Defective lung macrophage function in lung cancer ± chronic obstructive pulmonary disease (COPD/emphysema)-mediated by cancer cell production of PGE2?

In chronic obstructive pulmonary disease (COPD/emphysema) we have shown a reduced ability of lung and alveolar (AM) macrophages to phagocytose apoptotic cells (defective 'efferocytosis'), associated with evidence of secondary cellular necrosis and a resultant inflammatory response in the a...

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Veröffentlicht in:	PloS one 2013-04, Vol.8 (4), p.e61573-e61573
Hauptverfasser:	Dehle, Francis C, Mukaro, Violet R, Jurisevic, Craig, Moffat, David, Ahern, Jessica, Hodge, Greg, Jersmann, Hubertus, Reynolds, Paul N, Hodge, Sandra
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Alveoli Apoptosis Arachidonic acid Bronchoalveolar Lavage Fluid Cancer Cell Line, Tumor Chronic obstructive pulmonary disease Compartments Conditioning Cyclooxygenase 2 - metabolism Cyclooxygenase-2 Defects Demography Dinoprostone - biosynthesis Emphysema Female Hospitals Humans Indomethacin Inflammation Inflammatory response Inhibition Laboratories Lung - metabolism Lung - pathology Lung cancer Lung diseases Lung Neoplasms - complications Lung Neoplasms - pathology Macrophages Macrophages, Alveolar - pathology Male Mass spectrometry Medicine Metabolites Middle Aged Non-small cell lung carcinoma Obstructive lung disease Pathology Phagocytosis Prostaglandin E2 Pulmonary Disease, Chronic Obstructive - complications Pulmonary Disease, Chronic Obstructive - pathology Pulmonary Emphysema - complications Pulmonary Emphysema - pathology Respiratory tract Scientific imaging Smoking Subcellular Fractions - metabolism Tumors
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