HBx-induced NF-κB signaling in liver cells is potentially mediated by the ternary complex of HBx with p22-FLIP and NEMO

Sustained activation of NF-κB is one of the causative factors for various liver diseases, including liver inflammation and hepatocellular carcinoma (HCC). It has been known that activating the NF-κB signal by hepatitis B virus X protein (HBx) is implicated in the development of HCC. However, despite...

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Veröffentlicht in:	PloS one 2013-03, Vol.8 (3), p.e57331-e57331
Hauptverfasser:	Lim, Keo-Heun, Choi, Hyo Sun, Park, Yong Kwang, Park, Eun-Sook, Shin, Gu Choul, Kim, Doo Hyun, Ahn, Sung Hyun, Kim, Kyun-Hwan
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Apoptosis Biology c-FLIP protein Carcinoma, Hepatocellular - metabolism Carcinoma, Hepatocellular - pathology CASP8 and FADD-Like Apoptosis Regulating Protein - metabolism Cell growth Cell Line, Tumor Complex formation Electrophoretic mobility FLIP protein Gene Knockdown Techniques Genomics HBX protein Hepatitis Hepatitis B Hepatitis B virus - physiology Hepatocellular carcinoma Hepatocytes Hepatocytes - metabolism Hepatocytes - pathology Herpes viruses Humans I-kappa B Kinase - metabolism Immune system Kinases Liver Liver - metabolism Liver - pathology Liver cancer Liver diseases Liver Neoplasms - metabolism Liver Neoplasms - pathology Medical research Medicine NF-kappa B - metabolism NF-κB protein Pharmacology Protein Binding Proteins Recruitment Regulation RNA, Small Interfering - metabolism Signal Transduction Signaling Trans-Activators - metabolism Virus Replication Viruses
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