Statin therapy and mortality in HIV-infected individuals; a Danish nationwide population-based cohort study

Recent studies have suggested that statins possess diverse immune modulatory and anti-inflammatory properties. As statins might attenuate inflammation, statin therapy has been hypothesized to reduce mortality in HIV-infected individuals. We therefore used a Danish nationwide cohort of HIV-infected i...

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Veröffentlicht in:	PloS one 2013-03, Vol.8 (3), p.e52828-e52828
Hauptverfasser:	Rasmussen, Line D, Kronborg, Gitte, Larsen, Carsten S, Pedersen, Court, Gerstoft, Jan, Obel, Niels
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired immune deficiency syndrome Adult AIDS Anti-HIV Agents - pharmacology Anti-HIV Agents - therapeutic use Anti-inflammatory agents Antiretroviral drugs Antiretroviral Therapy, Highly Active Cardiovascular disease Cardiovascular diseases Cardiovascular Diseases - drug therapy Cardiovascular Diseases - mortality Cohort analysis Comorbidity Denmark Denmark - epidemiology Diabetes mellitus Diabetes Mellitus - drug therapy Diabetes Mellitus - mortality Diagnosis Failure analysis Female Forecasts and trends Health risk assessment Highly active antiretroviral therapy HIV HIV Infections - drug therapy HIV Infections - mortality HIV patients Human immunodeficiency virus Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use Identification methods Inflammation Male Medical diagnosis Medicine Middle Aged Mortality Patient outcomes Physiological aspects Poisson density functions Population studies Population-based studies Predictive control Regression analysis Renal Insufficiency, Chronic - drug therapy Renal Insufficiency, Chronic - mortality Statins Statistical analysis Studies Survival Analysis Therapy Viral Load
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