Systemic inflammation in progressive multiple sclerosis involves follicular T-helper, Th17- and activated B-cells and correlates with progression

Pathology studies of progressive multiple sclerosis (MS) indicate a major role of inflammation including Th17-cells and meningeal inflammation with ectopic lymphoid follicles, B-cells and plasma cells, the latter indicating a possible role of the newly identified subset of follicular T-helper (TFH)...

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Veröffentlicht in:	PloS one 2013-03, Vol.8 (3), p.e57820-e57820
Hauptverfasser:	Romme Christensen, Jeppe, Börnsen, Lars, Ratzer, Rikke, Piehl, Fredrik, Khademi, Mohsen, Olsson, Tomas, Sørensen, Per Soelberg, Sellebjerg, Finn
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Age Autoimmune diseases B cells B-Lymphocytes - metabolism B-Lymphocytes - pathology Biology Blood Blood cells CD4 antigen CD8 antigen CD83 antigen Cell Adhesion Molecules - cerebrospinal fluid Cell Adhesion Molecules - genetics Cerebrospinal fluid Complications and side effects Correlation analysis Cytokines Cytometry DC-SIGN protein Dendritic cells Dendritic Cells - metabolism Dendritic Cells - pathology Development and progression Disease Disease Progression Female Flow Cytometry Fluid flow Follicles Gene Expression Gene flow Genetic aspects Helper cells Humans Inducible T-Cell Co-Stimulator Protein - genetics Inducible T-Cell Co-Stimulator Protein - metabolism Inflammation Inflammation - cerebrospinal fluid Inflammation - genetics Inflammation - pathology Interleukin Interleukin 21 Interleukin 23 Interleukin-21 Receptor alpha Subunit - genetics Interleukin-21 Receptor alpha Subunit - metabolism Interleukin-23 - cerebrospinal fluid Interleukin-23 - genetics Interleukins - cerebrospinal fluid Interleukins - genetics Lectins, C-Type - genetics Lymphocyte Activation Lymphocytes B Lymphocytes T Male Medicine Middle Aged Monocytes Monocytes - metabolism Monocytes - pathology Multiple sclerosis Multiple Sclerosis, Chronic Progressive - cerebrospinal fluid Multiple Sclerosis, Chronic Progressive - genetics Multiple Sclerosis, Chronic Progressive - pathology Neurology Neurosciences Pathology Patients Peripheral blood Physiological aspects Plasma cells Prognosis Receptors, Cell Surface - genetics Receptors, Interleukin - genetics Receptors, Interleukin - metabolism Rodents Studies T cell receptors Th17 Cells - metabolism Th17 Cells - pathology
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