Hyperuricemia is an independent risk factor for new onset micro-albuminuria in a middle-aged and elderly population: a prospective cohort study in taiwan
Hyperuricemia is now regarded as a risk factor for cardiovascular disease. Micro-albuminuria is associated with increased risk for cardiovascular disease and chronic kidney disease. We hypothesized that elevated serum uric acid (UA) is associated with development of micro-albuminuria in the general...
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| Veröffentlicht in: | PloS one 2013-04, Vol.8 (4), p.e61450-e61450 |
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| creator | Chang, Hung-Yu Lee, Pei-Hsien Lei, Chen-Chou Tung, Chun-Wu Hsu, Yung-Chien Huang, Tung-Jung Lu, Long-Chuan Lin, Chun-Liang |
| description | Hyperuricemia is now regarded as a risk factor for cardiovascular disease. Micro-albuminuria is associated with increased risk for cardiovascular disease and chronic kidney disease. We hypothesized that elevated serum uric acid (UA) is associated with development of micro-albuminuria in the general population.
We conducted a community-based prospective cohort study. A total of 1862 subjects from southern Taiwan, all older than 40 years, were screened and 993 of these participants without micro-albuminuria were followed for 4 years. Urinary albumin-to-creatinine ratio was measured two times per year. A multiple linear regression model indicated that serum UA was independently associated with ln(ACR) after adjustment for 8 factors (age, sex, and 6 metabolic metrics) (β = 0.194, p |
| doi_str_mv | 10.1371/journal.pone.0061450 |
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We conducted a community-based prospective cohort study. A total of 1862 subjects from southern Taiwan, all older than 40 years, were screened and 993 of these participants without micro-albuminuria were followed for 4 years. Urinary albumin-to-creatinine ratio was measured two times per year. A multiple linear regression model indicated that serum UA was independently associated with ln(ACR) after adjustment for 8 factors (age, sex, and 6 metabolic metrics) (β = 0.194, p<0.01). Logistic regression analysis indicated that each 1 mg/dL increase of UA was associated with a 1.42-fold increased risk of micro-albuminuria after adjustment for the same 8 factors (OR = 1.42, 95% CI: 1.27-1.59, p<0.01). A Cox regression model using subjects with serum UA less than 5 mg/dL as reference group indicated higher hazard ratios (HRs) only found in subjects with serum UA more than 7 mg/dL (HR = 3.54, 95% CI: 2.11-5.93, p<0.01) and not in subjects with serum UA of 5 to 7 mg/dL (HR = 1.30, 95% CI: 0.82-2.07, p = 0.15).
Hyperuricemia is significantly associated with micro-albuminuria in middle-aged and elderly males and females from a general population in Taiwan. Elevated serum UA is an independent predictor for development of micro-albuminuria in this population.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0061450</identifier><identifier>PMID: 23637835</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Age Factors ; Aged ; Aged, 80 and over ; Albuminuria ; Albuminuria - complications ; Albuminuria - epidemiology ; Blood pressure ; Cardiovascular disease ; Cardiovascular diseases ; Chinese medicine ; Cohort analysis ; Complications and side effects ; Creatinine ; Diabetes ; Enzymes ; Family medical history ; Female ; Females ; Geriatrics ; Health risk assessment ; Health risks ; Hospitals ; Humans ; Hypertension ; Hyperuricemia ; Hyperuricemia - complications ; Incidence ; Kidney diseases ; Laboratories ; Male ; Males ; Medicine ; Metabolic syndrome ; Middle age ; Middle Aged ; Nephrology ; Odds Ratio ; Older people ; Population ; Population studies ; Prospective Studies ; Regression analysis ; Regression models ; Risk Factors ; Rodents ; Sex Factors ; Studies ; Survival Analysis ; Taiwan - epidemiology ; Uric acid ; Uric Acid - blood</subject><ispartof>PloS one, 2013-04, Vol.8 (4), p.e61450-e61450</ispartof><rights>COPYRIGHT 2013 Public Library of Science</rights><rights>2013 Chang et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2013 Chang et al 2013 Chang et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c758t-c4601b0a3350cf2b447b1589671eb8631099c760bfae179fff9a72b93ea2a6563</citedby><cites>FETCH-LOGICAL-c758t-c4601b0a3350cf2b447b1589671eb8631099c760bfae179fff9a72b93ea2a6563</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3634806/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3634806/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2101,2927,23865,27923,27924,53790,53792,79471,79472</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23637835$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Abe, Hideharu</contributor><creatorcontrib>Chang, Hung-Yu</creatorcontrib><creatorcontrib>Lee, Pei-Hsien</creatorcontrib><creatorcontrib>Lei, Chen-Chou</creatorcontrib><creatorcontrib>Tung, Chun-Wu</creatorcontrib><creatorcontrib>Hsu, Yung-Chien</creatorcontrib><creatorcontrib>Huang, Tung-Jung</creatorcontrib><creatorcontrib>Lu, Long-Chuan</creatorcontrib><creatorcontrib>Lin, Chun-Liang</creatorcontrib><title>Hyperuricemia is an independent risk factor for new onset micro-albuminuria in a middle-aged and elderly population: a prospective cohort study in taiwan</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Hyperuricemia is now regarded as a risk factor for cardiovascular disease. Micro-albuminuria is associated with increased risk for cardiovascular disease and chronic kidney disease. We hypothesized that elevated serum uric acid (UA) is associated with development of micro-albuminuria in the general population.
We conducted a community-based prospective cohort study. A total of 1862 subjects from southern Taiwan, all older than 40 years, were screened and 993 of these participants without micro-albuminuria were followed for 4 years. Urinary albumin-to-creatinine ratio was measured two times per year. A multiple linear regression model indicated that serum UA was independently associated with ln(ACR) after adjustment for 8 factors (age, sex, and 6 metabolic metrics) (β = 0.194, p<0.01). Logistic regression analysis indicated that each 1 mg/dL increase of UA was associated with a 1.42-fold increased risk of micro-albuminuria after adjustment for the same 8 factors (OR = 1.42, 95% CI: 1.27-1.59, p<0.01). A Cox regression model using subjects with serum UA less than 5 mg/dL as reference group indicated higher hazard ratios (HRs) only found in subjects with serum UA more than 7 mg/dL (HR = 3.54, 95% CI: 2.11-5.93, p<0.01) and not in subjects with serum UA of 5 to 7 mg/dL (HR = 1.30, 95% CI: 0.82-2.07, p = 0.15).
Hyperuricemia is significantly associated with micro-albuminuria in middle-aged and elderly males and females from a general population in Taiwan. Elevated serum UA is an independent predictor for development of micro-albuminuria in this population.</description><subject>Age Factors</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Albuminuria</subject><subject>Albuminuria - complications</subject><subject>Albuminuria - epidemiology</subject><subject>Blood pressure</subject><subject>Cardiovascular disease</subject><subject>Cardiovascular diseases</subject><subject>Chinese medicine</subject><subject>Cohort analysis</subject><subject>Complications and side effects</subject><subject>Creatinine</subject><subject>Diabetes</subject><subject>Enzymes</subject><subject>Family medical history</subject><subject>Female</subject><subject>Females</subject><subject>Geriatrics</subject><subject>Health risk assessment</subject><subject>Health risks</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Hyperuricemia</subject><subject>Hyperuricemia - complications</subject><subject>Incidence</subject><subject>Kidney diseases</subject><subject>Laboratories</subject><subject>Male</subject><subject>Males</subject><subject>Medicine</subject><subject>Metabolic syndrome</subject><subject>Middle age</subject><subject>Middle Aged</subject><subject>Nephrology</subject><subject>Odds Ratio</subject><subject>Older people</subject><subject>Population</subject><subject>Population studies</subject><subject>Prospective Studies</subject><subject>Regression analysis</subject><subject>Regression models</subject><subject>Risk Factors</subject><subject>Rodents</subject><subject>Sex Factors</subject><subject>Studies</subject><subject>Survival Analysis</subject><subject>Taiwan - epidemiology</subject><subject>Uric acid</subject><subject>Uric Acid - blood</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNk1trFDEUxwdRbK1-A9GAIPqwazLJZGZ8EEpRWygUvL2GTC67qdlkTDKt-1H8tp5tt6UrfZBhLpz5nf-55Jyqek7wnNCWvDuPUwrSz8cYzBxjTliDH1T7pKf1jNeYPrzzvVc9yfkc44Z2nD-u9mrKadvRZr_6c7weTZqSU2blJHIZyYBc0GY08AgFJZd_IitViQlZuIO5RDFkU9DKqRRn0g_TygVQAO-AJJi19mYmF0aDlkbGa5P8Go1xnLwsLob3QI0p5tGo4i4MUnEZU0G5THq90SjSXcrwtHpkpc_m2fZ9UH3_9PHb0fHs9OzzydHh6Uy1TVdminFMBiwpbbCy9cBYO5Cm63lLzNBxSnDfq5bjwUpD2t5a28u2HnpqZC15w-lB9fJad_Qxi21XsyCUcdIwAIA4uSZ0lOdiTG4l01pE6cSVIaaFkKk45Y3AhGgMoW3bcNZoBYkxbaHvlBDLWANaH7bRpmFltIIWJ-l3RHf_BLcUi3gh4MRYhzfpvtkKpPhrMrmIlcvKeC-DidNV3h3re6gY0Ff_oPdXt6UWEgpwwUaIqzai4pC1Ha4poy1Q83souDTMjYIRtA7sOw5vdxyAKeZ3WcgpZ3Hy9cv_s2c_dtnXd9ilkb4sc_TTZrDyLsiuQZjSnJOxt00mWGw26KYbYrNBYrtB4Pbi7gHdOt2sDP0LJBEXfw</recordid><startdate>20130424</startdate><enddate>20130424</enddate><creator>Chang, Hung-Yu</creator><creator>Lee, Pei-Hsien</creator><creator>Lei, Chen-Chou</creator><creator>Tung, Chun-Wu</creator><creator>Hsu, Yung-Chien</creator><creator>Huang, Tung-Jung</creator><creator>Lu, Long-Chuan</creator><creator>Lin, Chun-Liang</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20130424</creationdate><title>Hyperuricemia is an independent risk factor for new onset micro-albuminuria in a middle-aged and elderly population: a prospective cohort study in taiwan</title><author>Chang, Hung-Yu ; Lee, Pei-Hsien ; Lei, Chen-Chou ; Tung, Chun-Wu ; Hsu, Yung-Chien ; Huang, Tung-Jung ; Lu, Long-Chuan ; Lin, Chun-Liang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c758t-c4601b0a3350cf2b447b1589671eb8631099c760bfae179fff9a72b93ea2a6563</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Age Factors</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Albuminuria</topic><topic>Albuminuria - complications</topic><topic>Albuminuria - epidemiology</topic><topic>Blood pressure</topic><topic>Cardiovascular disease</topic><topic>Cardiovascular diseases</topic><topic>Chinese medicine</topic><topic>Cohort analysis</topic><topic>Complications and side effects</topic><topic>Creatinine</topic><topic>Diabetes</topic><topic>Enzymes</topic><topic>Family medical history</topic><topic>Female</topic><topic>Females</topic><topic>Geriatrics</topic><topic>Health risk assessment</topic><topic>Health risks</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Hyperuricemia</topic><topic>Hyperuricemia - complications</topic><topic>Incidence</topic><topic>Kidney diseases</topic><topic>Laboratories</topic><topic>Male</topic><topic>Males</topic><topic>Medicine</topic><topic>Metabolic syndrome</topic><topic>Middle age</topic><topic>Middle Aged</topic><topic>Nephrology</topic><topic>Odds Ratio</topic><topic>Older people</topic><topic>Population</topic><topic>Population studies</topic><topic>Prospective Studies</topic><topic>Regression analysis</topic><topic>Regression models</topic><topic>Risk Factors</topic><topic>Rodents</topic><topic>Sex Factors</topic><topic>Studies</topic><topic>Survival Analysis</topic><topic>Taiwan - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chang, Hung-Yu</au><au>Lee, Pei-Hsien</au><au>Lei, Chen-Chou</au><au>Tung, Chun-Wu</au><au>Hsu, Yung-Chien</au><au>Huang, Tung-Jung</au><au>Lu, Long-Chuan</au><au>Lin, Chun-Liang</au><au>Abe, Hideharu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hyperuricemia is an independent risk factor for new onset micro-albuminuria in a middle-aged and elderly population: a prospective cohort study in taiwan</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2013-04-24</date><risdate>2013</risdate><volume>8</volume><issue>4</issue><spage>e61450</spage><epage>e61450</epage><pages>e61450-e61450</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Hyperuricemia is now regarded as a risk factor for cardiovascular disease. Micro-albuminuria is associated with increased risk for cardiovascular disease and chronic kidney disease. We hypothesized that elevated serum uric acid (UA) is associated with development of micro-albuminuria in the general population.
We conducted a community-based prospective cohort study. A total of 1862 subjects from southern Taiwan, all older than 40 years, were screened and 993 of these participants without micro-albuminuria were followed for 4 years. Urinary albumin-to-creatinine ratio was measured two times per year. A multiple linear regression model indicated that serum UA was independently associated with ln(ACR) after adjustment for 8 factors (age, sex, and 6 metabolic metrics) (β = 0.194, p<0.01). Logistic regression analysis indicated that each 1 mg/dL increase of UA was associated with a 1.42-fold increased risk of micro-albuminuria after adjustment for the same 8 factors (OR = 1.42, 95% CI: 1.27-1.59, p<0.01). A Cox regression model using subjects with serum UA less than 5 mg/dL as reference group indicated higher hazard ratios (HRs) only found in subjects with serum UA more than 7 mg/dL (HR = 3.54, 95% CI: 2.11-5.93, p<0.01) and not in subjects with serum UA of 5 to 7 mg/dL (HR = 1.30, 95% CI: 0.82-2.07, p = 0.15).
Hyperuricemia is significantly associated with micro-albuminuria in middle-aged and elderly males and females from a general population in Taiwan. Elevated serum UA is an independent predictor for development of micro-albuminuria in this population.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>23637835</pmid><doi>10.1371/journal.pone.0061450</doi><tpages>e61450</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2013-04, Vol.8 (4), p.e61450-e61450 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1346154563 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS); EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Age Factors Aged Aged, 80 and over Albuminuria Albuminuria - complications Albuminuria - epidemiology Blood pressure Cardiovascular disease Cardiovascular diseases Chinese medicine Cohort analysis Complications and side effects Creatinine Diabetes Enzymes Family medical history Female Females Geriatrics Health risk assessment Health risks Hospitals Humans Hypertension Hyperuricemia Hyperuricemia - complications Incidence Kidney diseases Laboratories Male Males Medicine Metabolic syndrome Middle age Middle Aged Nephrology Odds Ratio Older people Population Population studies Prospective Studies Regression analysis Regression models Risk Factors Rodents Sex Factors Studies Survival Analysis Taiwan - epidemiology Uric acid Uric Acid - blood |
| title | Hyperuricemia is an independent risk factor for new onset micro-albuminuria in a middle-aged and elderly population: a prospective cohort study in taiwan |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-09T05%3A45%3A58IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Hyperuricemia%20is%20an%20independent%20risk%20factor%20for%20new%20onset%20micro-albuminuria%20in%20a%20middle-aged%20and%20elderly%20population:%20a%20prospective%20cohort%20study%20in%20taiwan&rft.jtitle=PloS%20one&rft.au=Chang,%20Hung-Yu&rft.date=2013-04-24&rft.volume=8&rft.issue=4&rft.spage=e61450&rft.epage=e61450&rft.pages=e61450-e61450&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0061450&rft_dat=%3Cgale_plos_%3EA478023437%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1346154563&rft_id=info:pmid/23637835&rft_galeid=A478023437&rft_doaj_id=oai_doaj_org_article_011d0671f75645dcb0a4df053311f445&rfr_iscdi=true |