Anti-cancer drugs elicit re-expression of UDP-glucuronosyltransferases in melanoma cells

The UDP-glucuronosyltransferase (UGT) family of enzymes plays a vital role in the detoxification of carcinogens as well as clearance of anti-cancer drugs. In humans, 19 UGT family members have been identified and are expressed in a tissue specific manner throughout the body. However, the UGTs have n...

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Veröffentlicht in:	PloS one 2012-10, Vol.7 (10), p.e47696
Hauptverfasser:	Dellinger, Ryan W, Matundan, Harry H, Ahmed, Amelia S, Duong, Priscilla H, Meyskens, Jr, Frank L
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Anticancer properties Antineoplastic Agents - pharmacology Biology Cancer Cancer cells Cancer therapies Carcinogens Cell Line, Tumor Dacarbazine - analogs & derivatives Detoxification Development and progression Dosage and administration Doxorubicin Drug metabolism Drug resistance Drug Resistance, Neoplasm - drug effects Drug Resistance, Neoplasm - physiology Drug therapy Drugs Enzymes Epirubicin Etiology Gene Expression Regulation - drug effects Gene Knockdown Techniques Genetic aspects Glucuronosyltransferase Glucuronosyltransferase - genetics Glucuronosyltransferase - metabolism Humans Indoles Medicine Melanocytes Melanocytes - metabolism Melanoma Melanoma - metabolism Metabolism Metastases Metastasis Mutation Physiological aspects Skin cancer Sulfonamides Temozolomide Toxicity Tumor cell lines UDP-glucuronosyltransferase Vemurafenib
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