Adhesion of Trypanosoma cruzi trypomastigotes to fibronectin or laminin modifies tubulin and paraflagellar rod protein phosphorylation

The unicellular parasite Trypanosoma cruzi is the causative agent of Chagaś disease in humans. Adherence of the infective stage to elements of the extracellular matrix (ECM), as laminin and fibronectin, is an essential step in host cell invasion. Although members of the gp85/TS, as Tc85, were identi...

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Veröffentlicht in:	PloS one 2012-10, Vol.7 (10), p.e46767-e46767
Hauptverfasser:	Mattos, Eliciane C, Schumacher, Robert I, Colli, Walter, Alves, Maria Julia M
Format:	Artikel
Sprache:	eng
Schlagworte:	Albumin Biology Bovine serum albumin Cell division Cell-free system Chagas disease Cytoskeleton Dephosphorylation Extracellular matrix Fibronectin Fibronectins Fibronectins - metabolism Gels Heparan sulfate Immunoblotting Immunofluorescence Immunoglobulins Immunoprecipitation Infections Infective stages Kinases Laboratory animals Laminin Laminin - metabolism Localization Mediation Motility Parasites Phosphatase Phosphoproteins Phosphorylation Proteins Protozoa Protozoan Proteins - metabolism Serum albumin Signal transduction Signal Transduction - physiology Signaling Spots Structural members Trypanosoma cruzi Trypanosoma cruzi - metabolism Trypanosoma cruzi - physiology Trypomastigotes Tubulin Tubulin - metabolism
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