Diagnosis of bladder cancer recurrence based on urinary levels of EOMES, HOXA9, POU4F2, TWIST1, VIM, and ZNF154 hypermethylation

Non muscle invasive bladder cancer (NMIBC) has the highest recurrence rate of any malignancy and as many as 70% of patients experience relapse. Aberrant DNA methylation is present in all bladder tumors and can be detected in urine specimens. Previous studies have identified DNA methylation markers t...

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Veröffentlicht in:	PloS one 2012-10, Vol.7 (10), p.e46297-e46297
Hauptverfasser:	Reinert, Thomas, Borre, Michael, Christiansen, Anders, Hermann, Gregers G, Ørntoft, Torben F, Dyrskjøt, Lars
Format:	Artikel
Sprache:	eng
Schlagworte:	Aberration Adult Aged Aged, 80 and over Analysis Biology Biomarkers Biomarkers, Tumor - urine Bladder Bladder cancer Cancer Cancer diagnosis Cancer recurrence Deoxyribonucleic acid Diagnostic systems DNA DNA Methylation Epigenesis, Genetic Epigenetics Female Health aspects Health risk assessment Histology Homeodomain Proteins - genetics Homeodomain Proteins - urine Humans Invasiveness Male Malignancy Medical diagnosis Medicine Methylation Middle Aged Muscles Mutation Neoplasm Invasiveness Neoplasm Recurrence, Local Nuclear Proteins - genetics Nuclear Proteins - urine Patients Prognosis Quality Regression analysis Sediments Sensitivity Surveillance T-Box Domain Proteins - genetics T-Box Domain Proteins - urine Transcription Factor Brn-3B - genetics Transcription Factor Brn-3B - urine Tumors Twist-Related Protein 1 - genetics Twist-Related Protein 1 - urine Urinary bladder Urinary Bladder Neoplasms - diagnosis Urinary Bladder Neoplasms - genetics Urinary Bladder Neoplasms - pathology Urinary Bladder Neoplasms - urine Urine Vimentin - genetics Vimentin - urine Zinc Fingers - genetics
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