Inhibition of Notch signaling by a γ-secretase inhibitor attenuates hepatic fibrosis in rats

Notch signaling is essential to the regulation of cell differentiation, and aberrant activation of this pathway is implicated in human fibrotic diseases, such as pulmonary, renal, and peritoneal fibrosis. However, the role of Notch signaling in hepatic fibrosis has not been fully investigated. In th...

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Veröffentlicht in:	PloS one 2012-10, Vol.7 (10), p.e46512-e46512
Hauptverfasser:	Chen, Yixiong, Zheng, Shaoping, Qi, Dan, Zheng, Shaojiang, Guo, Junli, Zhang, Shuling, Weng, Zhihong
Format:	Artikel
Sprache:	eng
Schlagworte:	Aberration Activated carbon Amyloid Precursor Protein Secretases - antagonists & inhibitors Animals Apoptosis Biology Carbon tetrachloride Cell activation Cell differentiation E-cadherin Enzyme Inhibitors - pharmacology Fibrosis Gene expression Growth factors Hepatocytes Hospitals Infectious diseases Inhibition Inhibitors Jagged1 protein Kidneys Laboratories Ligands Liver Liver cirrhosis Liver Cirrhosis - prevention & control Liver diseases Lung diseases Medicine Notch protein Notch3 protein Peritoneum Proteins Rats Receptors, Notch - antagonists & inhibitors Receptors, Notch - genetics Receptors, Notch - metabolism RNA, Small Interfering Rodents Science Secretase Signal transduction Signal Transduction - drug effects Signaling Studies Transforming growth factor-b1 Veterinary Science Vimentin
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