The alternative Epac/cAMP pathway and the MAPK pathway mediate hCG induction of leptin in placental cells

Pleiotropic effects of leptin have been identified in reproduction and pregnancy, particularly in the placenta, where it works as an autocrine hormone. In this work, we demonstrated that human chorionic gonadotropin (hCG) added to JEG-3 cell line or to placental explants induces endogenous leptin ex...

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Veröffentlicht in:	PloS one 2012-10, Vol.7 (10), p.e46216-e46216
Hauptverfasser:	Maymó, Julieta Lorena, Pérez Pérez, Antonio, Maskin, Bernardo, Dueñas, José Luis, Calvo, Juan Carlos, Sánchez Margalet, Víctor, Varone, Cecilia Laura
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Autocrine signalling Base Sequence Biology Blotting, Western Cell adhesion & migration Cell Line, Tumor Chorionic gonadotropin Chorionic Gonadotropin - physiology Chorionic gonadotropins Cyclic adenosine monophosphate Cyclic AMP - metabolism Cyclic AMP response element-binding protein Cyclic AMP-Dependent Protein Kinases - metabolism Cytokines DNA Primers Enzyme Activation Explants Female Gene expression Glycoproteins Gonadotropins Growth factors Guanine Nucleotide Exchange Factors - metabolism Hormones Humans In Vitro Techniques Inhibition Intracellular levels Kinases Leptin Leptin - biosynthesis MAP kinase MAP Kinase Signaling System Medicine Phosphorylation Pituitary (anterior) Placenta Placenta - metabolism Pregnancy Protein kinase A Proteins Rap1 protein Real-Time Polymerase Chain Reaction RNA Rodents Signal transduction Smooth muscle
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