Interaction between IRF6 and TGFA genes contribute to the risk of nonsyndromic cleft lip/palate

Previous evidence from tooth agenesis studies suggested IRF6 and TGFA interact. Since tooth agenesis is commonly found in individuals with cleft lip/palate (CL/P), we used four large cohorts to evaluate if IRF6 and TGFA interaction contributes to CL/P. Markers within and flanking IRF6 and TGFA genes...

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Veröffentlicht in:	PloS one 2012-09, Vol.7 (9), p.e45441-e45441
Hauptverfasser:	Letra, Ariadne, Fakhouri, Walid, Fonseca, Renata F, Menezes, Renato, Kempa, Inga, Prasad, Joanne L, McHenry, Toby G, Lidral, Andrew C, Moreno, Lina, Murray, Jeffrey C, Daack-Hirsch, Sandra, Marazita, Mary L, Castilla, Eduardo E, Lace, Baiba, Orioli, Ieda M, Granjeiro, Jose M, Schutte, Brian C, Vieira, Alexandre R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal tissues Animals Binding sites Biology Biomedical research Brazil Cancer Cell cycle Cleft lip Cleft Lip - genetics Cleft Lip - metabolism Cleft lip/palate Cleft palate Cleft Palate - genetics Cleft Palate - metabolism Congenital defects Dentistry Dentists European Continental Ancestry Group Family medical history Genes Genetic aspects Genetic Predisposition to Disease - genetics Genetics Genotype Genotypes Growth factors Humans Interferon Interferon Regulatory Factors - genetics Interferon Regulatory Factors - metabolism Linkage Disequilibrium - genetics Markers Medicine Mice Orthodontics Pediatrics Physicians Polymorphism, Single Nucleotide - genetics Protein Binding Protein-protein interactions Public health Risk factors Studies Teeth Transforming Growth Factor alpha - genetics Transforming Growth Factor alpha - metabolism Transforming growth factors
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