Adenoviral delivery of angiotensin-(1-7) or angiotensin-(1-9) inhibits cardiomyocyte hypertrophy via the mas or angiotensin type 2 receptor

The counter-regulatory axis of the renin angiotensin system peptide angiotensin-(1-7) [Ang-(1-7)] has been identified as a potential therapeutic target in cardiac remodelling, acting via the mas receptor. Furthermore, we recently reported that an alternative peptide, Ang-(1-9) also counteracts cardi...

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Veröffentlicht in:	PloS one 2012-09, Vol.7 (9), p.e45564-e45564
Hauptverfasser:	Flores-Muñoz, Monica, Godinho, Bruno M D C, Almalik, Abdulaziz, Nicklin, Stuart A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - genetics Angiotensin AT2 receptors Angiotensin I - chemistry Angiotensin I - genetics Angiotensin I - metabolism Angiotensin II Animals Argipressin Biology Cardiomegaly - genetics Cardiomegaly - metabolism Cardiomegaly - therapy Cardiomyocytes Cardiovascular disease Cell Line Conditioning Diabetes Diabetic retinopathy Efficiency Enzymes Expression vectors Gene therapy Gene transfer Genetic Therapy Genetic Vectors Heart Heart diseases Humans Hypertension Hypertrophy Immunoblotting Isoproterenol Medicine Myocytes, Cardiac - metabolism Peptide Fragments - chemistry Peptide Fragments - genetics Peptide Fragments - metabolism Peptides Pharmacy Protein expression Proteins Proto-Oncogene Proteins - metabolism Rabbits Rats Receptor, Angiotensin, Type 2 - metabolism Receptors Receptors, G-Protein-Coupled - metabolism Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism Renin Rodents Transduction, Genetic Vasopressin
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