Identification of genes from the fungal pathogen Cryptococcus neoformans related to transmigration into the central nervous system

A mouse brain transmigration assessment (MBTA) was created to investigate the central nervous system (CNS) pathogenesis of cryptococcal meningoencephalitis. Two cryptococcal mutants were identified from a pool of 109 pre-selected mutants that were signature-tagged with the nourseothricin acetyltrans...

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Veröffentlicht in:	PloS one 2012-09, Vol.7 (9), p.e45083-e45083
Hauptverfasser:	Tseng, Hsiang-Kuang, Liu, Chang-Pan, Price, Michael S, Jong, Ambrose Y, Chang, Jui-Chih, Toffaletti, Dena L, Betancourt-Quiroz, Marisol, Frazzitta, Aubrey E, Cho, Wen-Long, Perfect, John R
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetyltransferase Acetyltransferases - metabolism Animals Biology Blood-brain barrier Blood-Brain Barrier - microbiology Brain Cell Adhesion Cell migration Central nervous system Central Nervous System - cytology Central Nervous System - microbiology Clinical medicine Cryptococcus Cryptococcus neoformans Cryptococcus neoformans - genetics Cryptococcus neoformans - growth & development Cryptococcus neoformans - physiology Endothelial Cells - cytology Endothelial Cells - microbiology Fungal infections Gene expression Genes, Fungal - genetics Genetic aspects Genetic Association Studies Genetic Testing Health aspects Hospitals Identification Infections Infectious diseases Kinases Leukocyte migration Macrophages Medicine Meningoencephalitis Mice Microvessels - cytology Models, Biological Mortality Mutants Mutation Mutation - genetics Pathogenesis Pathogens Phagocytosis Polymerase Chain Reaction Proteins Reproducibility of Results Research design Saccharomyces cerevisiae Temperature Transcytosis Transendothelial and Transepithelial Migration - genetics Yeast
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