Hedgehog pathway signaling regulates human colon carcinoma HT-29 epithelial cell line apoptosis and cytokine secretion

The Hedgehog (Hh) pathway is involved in embryogenesis and physiologic processes including cell survival and proliferation. We used the HT-29 and other human colon carcinoma cell lines to investigate Hh signaling and biological functions in colonic epithelial cells. HT-29 cells were cultured under d...

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Veröffentlicht in:	PloS one 2012-09, Vol.7 (9), p.e45332
Hauptverfasser:	Yoshimoto, Agnes N, Bernardazzi, Claudio, Carneiro, Antonio José V, Elia, Celeste C S, Martinusso, Cesonia A, Ventura, Grasiella M, Castelo-Branco, Morgana T L, de Souza, Heitor S P
Format:	Artikel
Sprache:	eng
Schlagworte:	Abnormalities Apoptosis Apoptosis - drug effects Apoptosis - genetics beta Catenin - genetics beta Catenin - metabolism Biology Bone Morphogenetic Protein 4 - genetics Bone Morphogenetic Protein 4 - metabolism Bone Morphogenetic Protein 7 - genetics Bone Morphogenetic Protein 7 - metabolism Breast cancer Butyrates - pharmacology CD95 antigen Cell culture Cell cycle Cell proliferation Cell survival Cell Survival - drug effects Cell Survival - genetics Chemokine CCL2 - genetics Chemokine CCL2 - metabolism Chemokines Chemotaxis Colon Colon cancer Colonic diseases Colonic Neoplasms - genetics Colonic Neoplasms - metabolism Colorectal cancer Cytokines Cytokines - metabolism Development and progression Embryogenesis Embryonic growth stage Enzyme-Linked Immunosorbent Assay Epithelial cells Exposure Fluorescent Antibody Technique Gene expression Genetic aspects Hedgehog protein Hedgehog Proteins - agonists Hedgehog Proteins - genetics Hedgehog Proteins - metabolism HT29 Cells Humans Immune response Immune system Immunofluorescence Inflammation Interleukin 8 Interleukin-8 - metabolism Kruppel-Like Transcription Factors - genetics Kruppel-Like Transcription Factors - metabolism Medicine Monocyte chemoattractant protein 1 Oncogene Proteins - genetics Oncogene Proteins - metabolism Physiological aspects Proteins Pyridines - pharmacology Pyrimidines - pharmacology Real-Time Polymerase Chain Reaction Signal transduction Signal Transduction - drug effects Signal Transduction - genetics Signaling Trans-Activators - genetics Trans-Activators - metabolism Transcription factors Veratrum Alkaloids - pharmacology Zinc Finger Protein GLI1 Zinc Finger Protein Gli2
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